During the past decade, isopolyoxotungstates (iso‐POTs) and their derivatives have been greatly developed due to their unique structures and potential applications in luminescence, magnetism, catalysis etc. This brief review is principally focused on the main research progress on iso‐POTs, iso‐POT‐based transition‐metal derivatives, iso‐POT‐based rare‐earth derivatives, iso‐POT‐based organometallic derivatives and iso‐POT‐based heterometallic derivatives, and gives a summary of some representative examples of their syntheses, structures and related properties. In addition, an outlook on the future of this area is presented in the final section. We believe that this systematic commentary on iso‐POTs and their derivatives will not only disclose a rich set of iso‐POT structures, but also reveal a more promising direction for the further functionalization of iso‐POTs.