Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess the effect of NFA on GABA-induced inward current in dorsal root ganglion (DRG) neurons of a chronic constriction injury (CCI) model. It was observed that 1–1,000 µmol/l GABA induced a concentration-dependent inward current in DRG neurons. Compared with pseudo-operated rats, the thermal withdrawal latency (TWL) of CCI rats significantly decreased (P<0.01); however, the TWLs of each NFA group (50 and 300 µmol/l) were significantly longer than that of the CCI group (P<0.01). In the CCI group, the response evoked by GABA (10−6-10−3 mol/l) was reduced in a concentration dependent manner compared with a normal control group (P<0.01), and the current amplitudes of CCI rats activated by the same concentrations of GABA (10−6-10−3 mol/l) were significantly decreased compared with the control group (P<0.05). The inward currents activated by 100 µmol/l GABA were suppressed by treatment with 1, 10 and 100 µmol/l NFA (5.32±3.51, 33.8±5.20, and 52.2±6.32%, respectively; P<0.05). The inverse potentials of GABA-induced currents were 9.87±1.32 and 9.64±1.24 mV with and without NFA, respectively (P<0.05). Pre-treatment with NFA exerted a strong inhibitory effect on the peak value of GABA-induced current, and the GABA-induced response was inhibited by the same concentrations of NFA (1, 10 and 100 µmol/l) in the control and CCI groups (P<0.05). The results suggest that NFA reduced the primary afferent depolarization (PAD) associated with neuropathic pain and mediated by the GABAA receptor. NFA may regulate neuropathic pain by inhibiting dorsal root reflexes, which are triggered PAD.
Wind power generation does not emit greenhouse gases or pollutants, but there are some carbon emissions from the manufacturing, transportation, operation, and waste disposal of wind turbines. Directly driven permanent magnet and doubly fed asynchronous wind turbines currently have the largest market share in China, but few Chinese studies have compared their differences in carbon reduction potential. This paper uses life cycle assessment (LCA) to quantitatively analyze the full life cycle carbon emissions of the two wind turbines to determine which type of wind turbine has greater carbon reduction potential, obtaining the following results. (1) The full life cycle greenhouse gas emissions of 2.5 MW directly driven permanent magnet and doubly fed asynchronous wind turbines are 8.48 and 10.43 g CO2/kWh, respectively. The direct‐driven permanent magnet wind turbine is superior in terms of carbon reduction. (2) The stage with the greatest impact and the greatest difference between the two wind turbines in the full life cycle is the production stage, during which the carbon emissions of the directly driven permanent magnet and doubly fed asynchronous wind turbines are 1.045 × 106 and 1.210 × 106 kg, respectively. (3) According to sensitivity analysis, proper waste disposal and transportation can reduce carbon emissions from wind turbines. These research findings can be used to help achieve carbon peaking and neutrality goals, as well as the technological development of wind power enterprises.
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