Dengue fever (DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004-2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612 (83.5%) occurred during the peak period from August to October. Additionally, 76% (190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes (I, IV, V) of DENV1, and one genotype each of DENV2 (cosmopolitan) and DENV3 (I) circulated in Fujian during [2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014]. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian.dengue virus, E gene, phylogenetic tree, epidemiology, etiology Citation:
The aim of the present study was to evaluate the relationship between human papillomavirus (HPV) viral load and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. HPV viral load was tested by hybrid capture (HC) II method in 69 normal women, 202 with CIN, and 236 with squamous cervical cancer (SCC). A significant difference in viral load was found between CIN I and CIN II + III. The risk of developing CIN and SCC estimated by OR (odds ratio) increased with elevated viral load (medium viral load: 13.6 for CIN and 54.6 for SCC, high viral load: 10.8 for CIN and 34.8 for SCC, respectively), with correspondent ORs (medium viral load: 11.3 for CIN and 69.4 for SCC, high viral load: 9.8 for CIN and 39.9 for SCC, respectively) after adjusted cofactors such as age, pregnancy, and so on. Hence, HPV viral load detected by HC II might be a useful predictor for women with high risk of development of CIN and cervical cancer.
This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments. The complete genome sequences of the H7N9 viruses from the same family cluster were highly homologous, and the four isolated viruses from the two family clusters exhibited the virologic features of the H7N9 virus, in terms of transmissibility, pathogenicity, host adaptation, and antiviral drug resistance. In addition, our findings indicated that the A/Fujian/18/2015 viral strain contained an additional hemagglutinin G225D substitution, which preferentially binds α2,6-linked sialic acids. The results of this study demonstrate that one family cluster was infected through common exposure to live poultry or contaminated environments, and the other was more likely to be infected through the human-to-human route.
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