Prevalence of genital human papillomavirus infection and genotypes among women from Fujian province, PR China

Wu, Dongmei; Cai, Lin; Huang, Meng; Zheng, Yizhen

doi:10.1016/j.ejogrb.2010.02.040

Cited by 23 publications

(27 citation statements)

References 22 publications

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“…The results showed that the average HPV infection rate was 22.3% in general gynaecological outpatients from Hangzhou over the past five years. This value was close to the HPV infection rate of 22.80% in gynaecological outpatients from the same region reported by Liu et al [12, 13] and the previously reported HPV infection rate of 26% across the country of China [6]. Our result is consistent with the HPV infection rate of 20–25% reported in general gynaecological outpatients from other countries [14]; however, it was much lower the HPV infection rate of 66.7% found in a high-risk population from this region reported by Wang et al [15] Differences in the study populations (general gynaecological outpatients vs. a high-risk population) may be the cause of the significant difference in the HPV infection rates within the same region.…”

Section: Discussionsupporting

confidence: 90%

Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011–2015

et al. 2017

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BackgroundHPV infection is the major pathogenic factor underlying cervical cancer and precancerous lesions. The cervical HPV infection rates in gynaecological outpatients from Hangzhou, China, were studied in the period from January 2011 to December 2015.MethodsExfoliated cervical cells were harvested from gynaecological outpatients in Hangzhou from January 2011 to December 2015. Twenty-one HPV subtypes were detected using flow-through hybridization. The HPV infection rates in various disease groups were compared using the Chi-square test. The infection rates of different HPV subtypes in different calendar years and in different age groups were analysed using the linear-by-linear association test and gamma value.ResultsA total of 43,804 patients were recruited, of whom 9752 (22.3%) were infected with HPV. The top five among the 21 HPV subtypes detected in terms of infection rates were HPV-16, −52, −58, −53 and −18. No significant differences (linear-by-linear association test) were found in the HPV infection rates when compared over the studied years (P > 0.05). However, the 15–24-year-old age group showed the highest HPV infection rate, and significant differences (linear-by-linear association test) were detected among the different age groups (P < 0.05). The HPV infection rates exhibited an upward trend in the 15–24-year-old and >24–34-year-old groups over the past five years. There were significant differences in the HPV infection rates among the disease groups (P < 0.05).ConclusionsHPV-16, −52 and −58 were the major HPV infection subtypes in Hangzhou, China. The 15–24-year-old age group had a relatively high HPV infection rate with an upward trend over the past five years and thus represented a population susceptible to HPV infection.

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Section: Discussionsupporting

confidence: 90%

Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011–2015

et al. 2017

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“…HPV45 is highly prevalent in all regions of the world and frequently identified in women with highgrade cervical intraepithelial neoplasia (CIN 2ϩ) and invasive cervical carcinoma (ICC), which account for 2 to 8% of cervical cancers (6,9,25). HPV genotypes 52 and 58 are prevalent in Asian populations, especially in China (5,14,15,28,29).…”

Section: Discussionmentioning

confidence: 99%

“…These genotypes are highly prevalent in all regions of the world and account for approximately 70% of all cancers of the cervix (2, 13, 25). HPV types 52 and 58 are rare in Western countries; however, they are prevalent in Asian populations, especially in China (5,14,15,28,29).Technologies available for HPV genotyping vary by method and platform and may offer type-specific characterization for a multitude of different high-and low-risk HPV types. For example, The Qiagen Hybrid Capture 2 HPV DNA (HC2) test and the Roche Amplicor HPV test (Amplicor) detect the DNA of 13 high-risk HPV types.…”

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Visual Detection of High-Risk Human Papillomavirus Genotypes 16, 18, 45, 52, and 58 by Loop-Mediated Isothermal Amplification with Hydroxynaphthol Blue Dye

et al. 2011

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A simple, rapid, sensitive, qualitative, colorimetric loop-mediated isothermal amplification (LAMP) with hydroxynaphthol blue dye (HNB) was established to detect high-risk human papillomavirus (HPV) genotypes 16, 18, 45, 52, and 58. All initial validation studies with the control DNA proved to be type specific. The colorimetric type-specific LAMP assay could achieve a sensitivity of 10 to 100 copies at 63°C for 65 min, comparable to that of real-time PCR. In order to evaluate the reliability of HPV type-specific LAMP, the assay was further evaluated with HPV DNAs from a panel of 294 clinical specimens whose HPV status was previously determined with a novel one-step typing method with multiplex PCR. The tested panel comprised 108 HPV DNA-negative samples and 186 HPV-DNA-positive samples of 14 genotypes. The results showed that the sensitivity of HPV type-specific LAMP for HPV types 16, 18, 45, 52, and 58 was 100%, 100%, 100%, 100%, and 100%, respectively, and the specificity was 100%, 98.5%, 100%, 98.8%, and 99.2%, respectively, compared with a novel one-step typing method with multiplex PCR. No cross-reactivity with other HPV genotypes was observed. In conclusion, this qualitative and colorimetric LAMP assay has potential usefulness for the rapid screening of HPV genotype 16, 18, 45, 52, and 58 infections, especially in resource-limited hospitals or rural clinics of provincial and municipal regions in China.It is well established that virtually all cervical cancers are caused by persistent high-risk oncogenic human papillomavirus (HPV) infections in the cervix. Thus, cervical screening could be improved by testing for the DNA of high-risk types of HPV as a primary screening tool (3, 9, 24). So far, at least 14 high-risk HPV genotypes have been shown to cause cervical cancer; those most important for cervical cancer are HPV types 16, 18, 45, 31, 33, 52, 58, and 35 (6, 7, 26). HPV16 is by far the predominant type, causing more than 50% of cancers; HPV18 follows, causing 14%; and HPV45 causes approximately 2.8%. These genotypes are highly prevalent in all regions of the world and account for approximately 70% of all cancers of the cervix (2, 13, 25). HPV types 52 and 58 are rare in Western countries; however, they are prevalent in Asian populations, especially in China (5,14,15,28,29).Technologies available for HPV genotyping vary by method and platform and may offer type-specific characterization for a multitude of different high-and low-risk HPV types. For example, The Qiagen Hybrid Capture 2 HPV DNA (HC2) test and the Roche Amplicor HPV test (Amplicor) detect the DNA of 13 high-risk HPV types. The Linear Array HPV genotyping test allows for the discrimination of 37 HPV genotypes. The PapilloCheck HPV screening test (Greiner Bio-One GmbH, Frickenhausen, Germany) is a PCR-based DNA microarray system for the detection and identification of 24 HPV genotypes (4, 7, 13, 25). However, these methods might not be suitable in primary clinical settings in developing countries or for field use, because of the sophisticated ...

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“…In southern China, a few epidemiologic researches had been performed to evaluate the HPV prevalence and genotype distribution in asymptomatic female population (Lin et al 2008;Wu et al, 2010;Yip et al, 2010;Chen et al, 2012), but little dada was available from outpatients (Lin et al, 2006;Xue et al, 2009). Due to the accessible anatomic site for sample collection and the well-established sample collecting method for cervix, we investigated the cervical HPV infection in women attending hospitals, to understand the age-specific and genotype-specific prevalence of HPV in Chaozhou City in recent 2 years, and to collect timely and sufficient information to support future vaccination program.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Genotype Distribution of Human Papillomavirus Infections in Women Attending Hospitals in Chaozhou of Guangdong Province

Chen

Luo²,

Lin³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Prevalence of genital human papillomavirus infection and genotypes among women from Fujian province, PR China

Cited by 23 publications

References 22 publications

Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011–2015

Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011–2015

Visual Detection of High-Risk Human Papillomavirus Genotypes 16, 18, 45, 52, and 58 by Loop-Mediated Isothermal Amplification with Hydroxynaphthol Blue Dye

Prevalence and Genotype Distribution of Human Papillomavirus Infections in Women Attending Hospitals in Chaozhou of Guangdong Province

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