Thec opper-catalyzed C(sp 2 ) À Ht rifluoromethylation of N,N-disubstituted hydrazones using the Tognir eagent is demonstrated to proceed efficiently for aliphatic aldehyde-derived substrates. Thes uccess of the reactions relied on the choice of the N,N-diphenylamino group as the terminal hydrazone amino group where N,N-dialkylamino groups were preferredf or (hetero)aromatic aldehyde-derived substrates.I na ddition,t he trifluoromethylated N-arylhydrazones are shownt ob eideal substrates for Fischer indole synthesis allowing as traightforward,t hree-step access to 2-trifluoromethylindole derivatives from simplea ldehydes.
Dipentaerythritol (DPE) has been prepared from a slurry of Pentaerythritol (PE) in sulfolane catalyzed by a low amount of sulfuric acid and was isolated with 16% yield (72% GPC purity) and 57% isolated selectivity.
Solvent-free synthesis of dipentaerythritol (DPE) from pentaerythritol (PE) and 3,3-bis(hydroxymethyl)oxetane (BHMO) was studied. DPE is known to be an attractive raw material in lubricating and coating fields. Reactivity of PE with BHMO was considered under acidic and basic conditions. After optimization of the reaction parameters, best yields of DPE were obtained using a Lewis acid catalyst (aluminum triflate) (33%) and using a basic catalyst (potassium hydroxide) (31%).
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