Transition-metal-catalyzed C-H activation has recently emerged as a powerful tool for the functionalization of organic molecules. While many efforts have focused on the functionalization of arenes and heteroarenes by this strategy in the past two decades, much less research has been devoted to the activation of non-acidic C-H bonds of alkyl groups. This Minireview highlights recent work in this area, with a particular emphasis on synthetically useful methods.

An efficient catalytic system has been developed for the synthesis of benzocyclobutenes by C-H activation of methyl groups. The optimal conditions employed a combination of Pd(OAc) 2 and P ( t )Bu 3 as catalyst, K 2CO 3 as the base, and DMF as solvent. A variety of substituted BCB were obtained under these conditions with yields in the 44-92% range, including molecules that are hardly accessible by other methods. The reaction was found limited to substrates bearing a quaternary benzylic carbon, but benzocyclobutenes bearing a tertiary benzylic carbon could be obtained indirectly from diesters by decarboxylation. Reaction substrates bearing a small substituent para to bromine gave an unexpected regioisomer that likely arose from a 1,4-palladium migration process. The formation of this "abnormal" regioisomer could be suppressed by introducing a larger subsituent para to bromine. DFT(B3PW91) calculations on the reaction of 2-bromo-tert-butylbenzene with Pd(P ( t )Bu 3) with different bases (acetate, bicarbonate, carbonate) showed the critical influence of the coordination mode of the base to induce both an easy C-H activation and to allow for a pathway for 1,4-palladium migration. Carbonate is shown to be more efficient than the two other bases because it can abstract the proton easily and at the same time maintain kappa (1)-coordination without extensive electronic reorganization.

Transition-metal-catalyzed C-H bond arylation has recently emerged as a powerful tool for the functionalization of organic molecules that may complement or even replace traditional catalytic cross-couplings. While many efforts have focused on the arylation of arenes and heteroarenes in the past two decades, less studies have been devoted to the arylation of nonacidic C-H bonds of alkyl groups. This tutorial review highlights recent work in this active area.

The palladium-catalyzed, two-step, one-pot borylation/Suzuki coupling (BSC) reaction was developed to synthesize sterically hindered 2,2'-disubstituted biphenyl and phenyl-indole compounds in a short, simple, and efficient manner from two easily accessible aryl halides. High yields can be obtained by choosing properly both components according to their rough electronic properties. The illustration of the utility of this method was provided by the solution and solid-phase synthesis of seven- or eight-membered biphenyl lactams 5a-e, as well as paullone 3a. These compounds exhibit moderate albeit significant cytotoxicities and may serve as structural models for future medicinal chemistry developments.

The first examples of efficient and general palladium-catalyzed intramolecular C(sp(3))-H arylation of (hetero)aryl chlorides, giving rise to a variety of valuable cyclobutarenes, indanes, indolines, dihydrobenzofurans, and indanones, are described. The use of aryl and heteroaryl chlorides significantly improves the scope of C(sp(3))-H arylation by facilitating the preparation of reaction substrates. Careful optimization studies have shown that the palladium ligand and the base/solvent combination are crucial to obtaining the desired class of product in high yields. Overall, three sets of reaction conditions employing P(t)Bu(3), PCyp(3), or PCy(3) as the palladium ligand and K(2)CO(3)/DMF or Cs(2)CO(3)/pivalic acid/mesitylene as the base/solvent combination allowed five different classes of products to be accessed using this methodology. In total, more than 40 examples of C-H arylation have been performed successfully. When several types of C(sp(3))-H bond were present in the substrate, the arylation was found to occur regioselectively at primary C-H bonds vs secondary or tertiary positions. In addition, in the presence of several primary C-H bonds, selectivity trends correlate with the size of the palladacyclic intermediate, with five-membered rings being favored over six- and seven-membered rings. Regio- and diastereoselectivity issues were studied computationally in the prototypal case of indane formation. DFT(B3PW91) calculations demonstrated that C-H activation is the rate-determining step and that the creation of a C-H agostic interaction, increasing the acidity of a geminal C-H bond, is a critical factor for the regiochemistry control.

The catalytic activation and functionalization of unactivated C(sp)-H bonds of alkyl groups has undergone intense development in recent years. In particular, a variety of directing groups as well as native functional groups have been employed in combination with palladium(II) catalysis in order to perform a variety of intermolecular, and to some extent intramolecular reactions. In parallel, inspired by precedents in C(sp)-H arylation, our group and others have developed a different approach, which is the focus of this Account. This strategy relies on the use of oxidative addition of a carbon-leaving group bond to palladium(0) to induce intramolecular C(sp)-H activation and the subsequent formation of a C(sp)-C(sp) or C(sp)-C(sp) bond. Since our first publication in 2003, the construction of olefins and, more interestingly, of an array of valuable monocyclic and polycyclic systems has been reported according to this principle. (Hetero)aryl bromides were initially employed as reactants, but the scope was later expanded to include (hetero)aryl chlorides and triflates, alkenyl bromides, carbamoyl chlorides and α-chloroamides. Mechanistic studies enabled a better understanding of the C-H activation step, which was proposed to occur through ambiphilic metal-ligand activation-6 (AMLA-6), also known as concerted metalation deprotonation (CMD), and a better rationalization of the observed selectivity patterns. Moreover, the wealth of accumulated experimental data indicate that the number of atoms separating the C-H bond from Pd and the type of C-H bond are the main factors controlling the site-selectivity of the C-H bond cleavage. Recent efforts have been devoted to the development of enantioselective reactions. To this purpose, two different strategies have been employed: a chiral ancillary ligand in combination with an achiral base, and a chiral base in combination with an achiral ligand, and allowed for the achievement of high enantioselectivities in the construction of both tri- and tetrasubstituted stereocenters. On the other hand, the current C-H activation-based ring-forming method was applied to the synthesis of pharmacologically active substances and agrochemicals, as well as complex natural products such as the aeruginosins, thereby demonstrating its great potential for step-economical organic synthesis.

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Palladacyclic intermediates effectively lower the high energy barrier to cleavage of a C(sp3)H bond. CH activation of benzylic gem‐dialkyl groups of bromo‐ and iodobenzenes produces olefins and cyclobutabenzenes, respectively, without homocoupling (see scheme).