BackgroundSystemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis.ObjectiveThe purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period.MethodsThe study comprised 35 psoriasis patients and 50 controls. Blood samples were obtained twice from the patients, one sample at the start and one at the end of a 12-week follow-up period. The following parameters were assessed in both groups: serum fasting glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, serum lipids, adiponectin, leptin, resistin, chemerin, omentin, vaspin, visfatin, retinol-binding protein 4, and high-sensitivity C-reactive protein (hs-CRP) levels; blood pressure; body mass index; and the psoriasis area severity index (PASI) scores.ResultsThe patients showed an improvement in the PASI score and a significant decrease in serum hs-CRP, omentin, and chemerin values. Moreover, at the start of the follow-up, the psoriasis patients had significantly lower levels of adiponectin and visfatin and significantly higher levels of vaspin and resistin than those of the control group. Visfatin levels correlated negatively with low-density lipoprotein (LDL) and cholesterol, while vaspin and omentin levels correlated positively with diastolic blood pressure. Decreased adiponectin levels correlated negatively with diastolic blood pressure and LDL.ConclusionPlasma levels of adipokines might be useful for evaluating the disease activity of psoriasis and its comorbidities.

Our results suggest that IGF-I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients.

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Ürtiker eritemli-ödemli papüller, anjiyoödem veya her ikisinin bir arada gelişmesiyle kendini gösteren bir deri hastalığıdır 1,2. Kronik spontan ürtiker (KSÜ), etiyolojisi tam olarak bilinmeyen, semptomların 6 haftadan daha uzun süre devam ettiği bir ürtiker formudur. KSÜ prevelansı %0,5-1 arasında değişmektedir 2 .Olguların yarısına anjiyoödem eşlik etmektedir 2 .

ÖzetReaktif perforan kollajenoz, yapısal olarak değişikliğe uğramış kollajen liflerinin epidermisteki hücrelerin arasından geçerek dışa atıldığı nadir bir hastalıktır. Kollajenoma perforans verrüsiforme olarak da bilinir. Diabetes mellitus ve kronik böbrek yetmezliği başta olmak üzere, hiperparatiroidizm, hipotiroidizm, lenfoma, malignite, nörodermatit, karaciğer hastalıkları, atopik dermatit, uyuz, AIDS (acquired immune deficiency syndrome), pulmoner fibrozis, herpes zoster enfeksiyonu ile de görülebilir. Kliniğimizde izlediğimiz diabetes mellitusu ve kronik böbrek yetmezliği olan kazanılmış reaktif perforan kollajenoz olgusunu literatür ışığında burada sunmaktayız. Anahtar kelimeler: Böbrek yetmezliği; diabetes mellitus; reaktif perforan kollajenoz AbstractReactive perforating collagenosis is a rare disease of elimination of altered collagen through the epidermis. Its synonym is collagenoma perforans verruciforme. The disease exists especially with diabetes mellitus and chronic renal failure and also with hyperparathyroidism, hypothyroidism, lymphoma, malignancy, neurodermatitis, liver disease, atopic dermatitis, scabies, acquired immune deficiency syndrome, pulmonary fibrosis and herpes zoster infection. In the review of literature, we present a case with acquired reactive perforating collagenosis associated with diabetes mellitus and renal failure.