Insulin‐like growth factor‐I gene polymorphism in acne vulgaris

Taşlı, L.; Turgut, Sebahat; Kaçar, Nida; Ayada, Ceylan; Çoban, Melis; Akçılar, Raziye; Ergin, Şeniz

doi:10.1111/j.1468-3083.2011.04299.x

Cited by 51 publications

(53 citation statements)

References 18 publications

(25 reference statements)

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“…9 A study by Tasli et al has suggested that insulin like growth factor-1 cytosine-adenine repeat (IGF-1 CA 19) polymorphism may contribute to a predisposition to acne in Turkish patients. 1 A study by Balta et al suggested that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne.…”

Section: Discussionmentioning

confidence: 99%

“…1 Even though acne is considered an androgen-dependent disease, occurrence of acne doesn't correlate with plasma androgen levels. Increased serum levels of insulin like growth factor (IGF-1) have been observed in adult women and men with acne, giving rise to the possibility of the role of growth hormone (GH), hyperinsulinemia, and IGF1 in acne.…”

Section: Introductionmentioning

confidence: 99%

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A comparative study of insulin resistance in acne vulgaris

et al. 2017

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INTRODUCTIONAcne is common skin problem among adolescents and young adults. The lesions can range from comedones to nodules and cysts leaving behind scars. It has a significant psychological impact on the patients. Acne is influenced by factors like diet, lifestyle and hormones. Recently the role of insulin resistance in acne is being widely researched.Acne vulgaris is a multifactorial disease of the skin. Even though acne is considered an androgen-dependent disease, occurrence of acne doesn't correlate with plasma androgen levels. Increased serum levels of insulin like growth factor (IGF-1) have been observed in adult women and men with acne, giving rise to the possibility of the role of growth hormone (GH), hyperinsulinemia, and IGF1 in acne. A positive correlation between the mean facial sebum excretion rate and serum IGF-1 levels has been demonstrated in post-adolescent acne patients. 2Some studies have discussed about the correlation between insulin resistance and severity of acne. This was attributed to increased blood glucose which in turn stimulates increased insulin secretion. Increased insulin decreases availability of binding protein for IGF-1 which facilitates the effects of IGF-1 on basal keratinocyte proliferation. Also insulin stimulates synthesis of androgens which can cause acne. In India, prevalence data from a dermatology clinic in a teaching hospital in Varanasi reported acne in 50.6% of boys and 38.13% of girls in the age group of 12-17 years. There are believed to be no gender differences in acne prevalence, although such difference are often reported and, very likely represent social biases. In clinics in the ABSTRACT Background: Acne is common skin problem among adolescents and young adults. Recently the role of insulin resistance in acne is being widely researched. The objectives of the study were to evaluate insulin resistance in acne, to compare the insulin resistance among cases and controls using homeostasis model assessment of insulin resistance Methods: 45 cases and 45 controls were recruited. Acne severity was graded using the global acne grading system (GAGS). Fasting glucose, fasting insulin levels were done and insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR). Results: We did not find any statistically significant difference in fasting insulin levels between cases and controls. However, a weak positive correlation between acne severity and fasting insulin levels (r =0.3, p=0.04) were observed. Fasting glucose levels and HOMA-IR values observed between cases and controls were not statistically significant (p=0.05, p=0.59 respectively). Conclusions: Our study did not suggest a major role of insulin resistance in acne.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparative study of insulin resistance in acne vulgaris

et al. 2017

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“…The highest physiological IGF-1 serum levels are found between the 15 th and 20 th year of life, which parallels the age with the highest acne prevalence. An IGF-1 gene polymorphism associated with acne has been identifi ed [ 18 ] . Insulin-like growth factor 1 triggers keratinocyte proliferation.…”

Section: Pathogenesismentioning

confidence: 99%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF‐1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life. Effective topical and systemic treatments are available. Optimal therapeutic results require continuous patient management over the course of the entire treatment period as well as adjustment of treatment modalities based on symptoms and disease severity.

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“…14, 15 Saleh et al, num estudo caso controlo, avaliaram os níveis séricos de hormona de crescimento e IGF-1 em pacientes com acne severa e compararam com os níveis de indiví-duos saudáveis e com acne moderada e leve, mostrando um aumento significativo da hormona de crescimento e da IGF-1, e consequentemente de vários androgénios, nos doentes com acne severo. 14 Tasli et al mostraram também que os polimorfismos do IGF-1 podem contribuir para um aumento da Figura 1 -Mecanismos pelos quais a IGF-1 potencia a ação andró-gena.…”

Section: Métodosunclassified

“…15 Para além disso, este estudo de Tasli et al mostrou que os pacientes com sintomatologia severa apresentam polimorfismos estaticamente diferentes dos indivíduos saudáveis e com acne leve a moderado. 15 Apesar da IGF-1 e da hormona de crescimento promoverem a inflamação e a comedogénese, são os fatores de transcrição da célula da glândula sebácea, os responsáveis pela regulação fina desse estímulo, sendo estes influenciados por fatores da dieta do indivíduo. 16,17 ( Fig.…”

Section: Métodosunclassified

Influência do Índice de Massa Corporal e da Dieta na Fisiopatologia da Acne Vulgaris

Silva

Velho

2018

SPDV

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RESUMO -Acne vulgar é uma patologia multifatorial que afeta principalmente adolescentes e jovens adultos e que se pode manifestar como lesões inflamatórias ou não inflamatórias. Esta doença acarreta morbilidade significativa, tanto física como psicológica. Está cientificamente comprovada a importância de diversos fatores, tanto genéticos como ambientais, na sua patogénese, tendo sido descritas nomeadamente associações com a dieta ocidental, índice de massa corporal excessivo e a resistência à insulina. Neste artigo é efetuada revisão da atual literatura relativa à acne vulgar, com enfoque na fisiopatologia e influência destes fatores na sua desregulação. O melhor conhecimento da fisiopatologia da acne e a avaliação crítica do papel da dieta, bem como da obesidade e da desregulação do sistema endócrino, podem contribuir para uma abordagem mais científica dos fatores exógenos que contribuem no início e agravamento desta interessante e frequente patologia. PALAVRAS-CHAVE -Acne Vulgaris/etiologia; Acne Vulgaris/fisiopatologia; Dieta; Índice de Massa Corporal; Obesidade. Influence of Body Mass Index and Diet on the Pathophysiology of Acne Vulgaris ABSTRACT -Acne vulgaris is a multifactorial disease that mainly affects adolescents and young adults and can present either with inflammatory or non-inflammatory lesions. This disease is responsible for significant morbidity, both physical and psychological. The importance of both genetic and environmental factors in its pathogenesis has been scientifically proven, and associations with the western diet, excessive body mass index and insulin resistance have been described. In this article we review the current literature on acne vulgaris, focusing on the pathophysiology and influence of these factors on its disregulation. A better knowledge of the physiopathology of acne and a critical evaluation of the influence of diet, body mass index and disruption of the endocrine system will allow a more scientific intervention on exogenous factors that contribute to the initiation and worsening of this interesting and frequent pathology. KEYWORDS - INTRODUÇÃOA acne vulgar é uma das patologias dermatológicas mais comuns na população geral, afetando 85% dos jovens adultos entre os 12 e os 25 anos.1 O género masculino é o mais afetado, particularmente nas formas mais severas da doença.2 A acne persiste em 64% dos indivíduos com 20-30 anos e 43% dos indivíduos com 30-40 anos.3 Afeta a unidade pilossebácea através de processos de hiperqueratose infundibular, hipersecreção sebácea, colonização microbiana (Propionibacterium acnes e Malassezia furfur) e mecanismos imunológicos. Manifesta-se com lesões inflamatórias (pápulas, pústulas ou nódulos) ou não inflamatórias (comedões abertos ou fechados) com localização mais comum na face, tronco e dorso, podendo ser classificada como ligeira, moderada e severa.4-6 A maior parte dos indivíduos desenvolve formas leves da doença, sendo que um pequeno número de

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Insulin‐like growth factor‐I gene polymorphism in acne vulgaris

Abstract: Our results suggest that IGF-I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients.

Cited by 51 publications

References 18 publications

A comparative study of insulin resistance in acne vulgaris

A comparative study of insulin resistance in acne vulgaris

Acne

Influência do Índice de Massa Corporal e da Dieta na Fisiopatologia da Acne Vulgaris

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