Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris

Çoban, Melis; Taşlı, L.; Turgut, Sebahat; Özkan, Şeyma; Ata, Melek Tunç; Akın, Fulya

doi:10.5021/ad.2016.28.1.74

Cited by 61 publications

(97 citation statements)

References 26 publications

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“…Conversely, in another study, both serum adiponectin and leptin levels were significantly decreased in psoriatic patients in comparison with the control group [58]. Other reports detected significantly lower levels of adiponectin and visfatin, and significantly higher levels of vaspin, omentin, chemerin, and resistin in psoriatic patients as compared to the control group [42, [59][60][61][62]. Of note, a meta-analysis including nine case-control studies, containing 421 psoriasis patients and 348 healthy controls, revealed a statistically significant association between serum resistin levels and psoriasis [59].…”

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confidence: 83%

“…Coban et al observed higher levels of chemerin in patients than in controls and a strongly positive correlation between the PASI score and chemerin [61]. Moreover, psoriatic patients showing an improvement in the PASI score correlating with a significant decrease in serum leptin, omentin, and chemerin values, and a significant increase of serum adiponectin levels [61].…”

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confidence: 91%

“…Interestingly, successful treatment of psoriasis with biologicals (i.e., infliximab and ustekinumab) or phototherapy (narrow band-UVB) was related to an increase of adiponectin serum levels and a decrease of leptin and resistin serum concentration [60]. Coban et al observed higher levels of chemerin in patients than in controls and a strongly positive correlation between the PASI score and chemerin [61]. Moreover, psoriatic patients showing an improvement in the PASI score correlating with a significant decrease in serum leptin, omentin, and chemerin values, and a significant increase of serum adiponectin levels [61].…”

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confidence: 97%

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Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Chiricozzi

Raimondo

Lembo

et al. 2016

Expert Review of Clinical Immunology

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Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation. Areas covered: This review provides an updated 'state-of-the-art' about the reciprocal contribution of a small subset of conventional cytokines and adipokines involved in chronic inflammatory pathways, upregulated in both psoriasis and increased adiposity. A systematic search was conducted using the PubMed Medline database for primary articles. Expert commentary: Because psoriasis is associated with increased adiposity, it would be important to define the contribution of chronic skin inflammation to the onset of obesity and vice versa. Clarifying the pathogenic mechanism underlying this association, a therapeutic strategy having favorable effects on both psoriasis and increased adiposity could be identified.

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confidence: 83%

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confidence: 91%

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confidence: 97%

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Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Chiricozzi

Raimondo

Lembo

et al. 2016

Expert Review of Clinical Immunology

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“…But recently Coban, et al [21] found out a relation between improvement in the Psoriasis Area Severity Index score in psoriasis patients and a significant reduction in high-sensitivity C-reactive protein serum level [21].…”

Section: Discussionmentioning

confidence: 99%

A New Biomarker in Patients with Vitiligo: A Case-Control Study

Ghaderi¹

2016

MOJI

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Background: CRP is an acute phase protein secreted in the blood stream by the liver in response to inflammatory cytokines such as IL6 and several other systemic inflammation biomarkers. Since inflammatory and immune factors have a key role in the pathogenesis of vitiligo, we aimed to assess the relationship between the serum level of hsCRP (as a biomarker for systemic inflammation) and the pathogenesis of vitiligo. Methods:In this case-control study, we enrolled patients who had referred to the Dermatology Department of Valiasr Dermatology Hospital, Birjand, Iran, during 2013. The patients were diagnosed to have vitiligo by a dermatologist. The patients were divided into two groups: those with type A vitiligo (generalized, n=30) and those with type B vitiligo (segmental, n=30). Moreover, 30 people who had the inclusion criteria and did not have vitiligo were selected among those referring to the clinic as the control group and matched with the other two groups. The serum hsCRP levels were checked for all the patients in the three groups and compared. Data were compared between the three groups and analyzed using SPSS software. Results:We did not find any significant difference between the three groups with respect to sex, age, smoking habit, BMI, and history of diabetes mellitus. The serum level of hsCRP was 4.76±1.31 mg/l in patients with type a vitiligo, 3.71±1.03 in those with type B vitiligo, and 3.01±1.08 in those in the control group. The highest level of serum hsCRP was related to patients with type A vitiligo while the lowest mean was related to the control group. The mean serum hsCRP level was significantly higher in patients with type A compared with those with type B and the control group (P<0.001). However, in patients with type B and the control groups no significant different was seen in this regard (P=0.053). Moreover, we found that the serum level of hsCRP did not differ between the three groups with respect to BMI. Conclusion:We found an association between increased serum hsCRP level and generalized vitiligo. The usage of hsCRP alone is neither sensitive, nor specific in diagnosis of vitiligo but this association could imply that hsCRP could intensify the severity of vitiligo thus serum hsCRP level might be useful for evaluating the disease activity of vitiligo as Novel biomarker.

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“…Recent studies have shown that patients with psoriasis are more inclined to be obese than healthy controls and that obesity is more common in patients with severe rather than mild psoriasis [38] . Finally, several adipokines have a central role in the low-grade inflammatory state in obese subjects, inducing autoimmune and inflammatory diseases such as T1D and psoriasis [39,40] . The aim of this review is to present an outlook of the roles of adipokines, cytokines, and microRNAs (miRNAs) in the onset and maintenance phases of these three diseases.…”

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confidence: 99%

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

Granata

Skarmoutsou²,

Trovato³

et al. 2016

Pathobiology

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Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases. In this review, we present an overview of the roles of adipokines, cytokines, and microRNAs in the pathogenesis and the progression of these three diseases.

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Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris

Cited by 61 publications

References 26 publications

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

A New Biomarker in Patients with Vitiligo: A Case-Control Study

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

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