A series of (E) -3- (3-(2,3-dihydro-3-methyl-2-oxo-3 H -benzoxazole-6-yl)-1-phenyl-1 H -pyrazole-4-yl)acrylamides (7a-k) were synthesized and evaluated for their in vitro inhibitory activities on COX-1 and COX-2 isoforms using a human whole blood assay as well as their antiplatelet profile against human platelet aggregation using arachidonic acid as agonists. Among the synthesized derivatives 7a-k, especially compound 7g exhibited dual anti-inflammatory and antiplatelet activity with selective COX-2 inhibition.
When the measurement and refractive results of the OLCR biometry were evaluated, it was observed that there was a very satisfactory result and a predictable device compatible with the current literature. The SRK/T formula, one of the new generation formulas, has shown high MAE and RE results in eyes with AL ≤ 22 mm, although not statistically significant. Other new generation formulas should be tried in these eyes.
Pseudoexfoliation syndrome (PES) is characterized by pseudoexfoliative material (PEM) accumulation in both ocular and systemic tissues and is considered to be a systemic disease. PEM is a grayish-white microfibrillary protein structure. PES is often seen in Scandinavian countries and in older ages, especially over the age of 60. 1,2 A study from our country has reported the PEX prevalence as 7.2% for the 50-60 years age group and 11.2% for those above 60 years. 3 The substance progressively accumulates in ocular tissues, mainly at the pupillary edge and lens anterior capsule, iridocorneal angle, ciliary
PurposeTo evaluate the effects of obesity on ocular blood flow including choroidal thickness and retrobulbar blood flow values in comparison with healthy subjectsMethodsThe 102 eyes of 102 female patients were included in this prospective study.Color Doppler ultrasonography (CDU) was used to evaluate the retrobulber vessels.Choroidal thickness was measured by using the optical coherence tomography (OCT). ResultsThere was a significant difference in IOP values within the groups with the highest values in group 3 and the lowest in group 1.There was also a positive correlation between BMI and IOP. The CT was found to be statistically significantly lower in group 2 and group 3 than in the control group at all measurement points. The choroidal thickness was also statistically significantly lower in group 3 than in group 2 at the subfoveal, nasal 500 µm, and the temporal 500 and 1000 µm measurement points.The mean CRA PSV and EDV values were lower in group 2 and group 3 than in group 1, while group 3 had the lowest mean CRA PSV value among the groups. When compared to group 1, the OA EDV value was lower only in group 3 while the OA PSV value was statistically significantly lower in group 3 than in both group 2 and group 1. There was no significant difference between the groups in terms of RI and PI.ConclusionsObesity can create a predisposition to ocular pathologies both by increasing the IOP and decreasing the retrobulbar and choroidal blood flow.
Background: Obesity affects microvascular structures. The effect of obesity on the ocular vascular system can be evaluated by changes in the choroidal thickness (CT) and retrobulbar blood flow (RBF). Objectives: To evaluate the CT and RBF parameters in obese patients with various body mass index (BMI) values and compare these parameters with normal weight, healthy subjects. Design: A prospective study. Methods: The study included 102 eyes of 102 female patients. Patients were divided into three groups according to BMI as group 1 with a BMI of 18.5–24.99 ( n = 32), normal weight group; group 2 with a BMI of 30–34.99 ( n = 35), as obese class I; and group 3 with a BMI of 35–39.99 ( n = 35), as obese class II. The peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index, and pulsatility index values of the central retinal artery (CRA) and ophthalmic artery (OA) were evaluated with color Doppler ultrasonography. CT was measured at the subfoveal area and at 500-µm intervals nasal and temporal to the fovea up to a distance of 1500 µm by using the enhanced depth imaging technique of optical coherence tomography. Intraocular pressure (IOP) was measured with a Goldmann applanation tonometry. Results: There was a significant difference in IOP values within the groups with the highest values in group 3 (17.6 ± 2.1 mmHg) and the lowest in group 1 (12.4 ± 1.7 mmHg). The CT in groups 2 and 3 was found to be statistically significantly lower than that in group 1 at all measurement points ( p < 0.001). There was a statistically significant negative correlation between CT at all measurement points and BMI ( p < 0.001). The mean CRA PSV, EDV, and OA EDV values were statistically significantly lower in each obese group than those values in group 1 ( p < 0.001). The OA PSV values were significantly lower in group 3 (36.5 ± 5.9 cm/s) than those in group 2 (43.8 ± 4 cm/s) and group 1 (44.6 ± 5.2 cm/s) ( p < 0.001). Also, significant associations were found between BMI and CRA PSV, CRA EDV, and OA PSV values ( p < 0.001). Conclusion: Obesity may predispose to eye pathologies by changing the ocular vascular circulation.
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