ABSTRACT:The reaction of 3-hydrazino-4,5,6-tri-phenylpyridazine 1 with phenylisothiocyanate in ethanol gave thiocarbamoylhydrazine 2 while in butanol gave triazolo [4,3-b]pyridazinethione 3. Reaction of 1 with ethyl chloroformate gave ethoxycarbamoylhydrazinopyridazine 5 which upon heating it furnished triazolopyridazine 6. Also, the reaction of 1 with chloroacetylchloride gave triazolopyridazine 7. Reaction of 1 with a number of aromatic aldehydes, D-glucose, and pyruvic acid gave the corresponding hydrazones 9,11. Oxidative cyclization of 9a,b gave triazolo [4,3-b]
Pyridazine derivatives R 0500 Pyridazine Derivatives and Related Compounds. Part 8. Synthesis of Different Heterocycles from 3-Hydrazinopyridazine. -Starting from compound (I), various heterocyclic compounds are synthesized in good yields. All compounds are evaluated for insecticidal, fungicidal, bactericidal and virucidal activities. None of the compounds exhibits significant activity. -(DEEB*, A.; HASSANEEN, M.; KOTB, M.; Heteroat. Chem. 16 (2005) 4, 278-284; Dep. Chem., Fac. Sci., Zagazig Univ., Zagazig, Egypt; Eng.) -C. Oppel
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