Nanoparticles (NPs) grafted with highly dense DNA strands are termed as spherical nucleic acids (SNAs), which have important applications benefiting from various unique properties unpossessed by naturally occurring nucleic acids. To overcome existing challenges toward an ideal SNA synthesis, herein, a very simple, while highly effective evaporative drying strategy featuring various long‐desired advantages, is reported. This includes record‐high DNA loading, generality for more NP materials, fully and quantitatively tunable DNA density, and readiness toward bulk production. The process requires almost zero care and the solid products are especially suitable for a long‐time storage without quality degradation. The research reveals a quick and highly efficient packing of thiol‐tagged DNA on the NP surface at the critical moment of drying, which refreshes previous knowledge on DNA conjugation chemistry. Based on this advancement, practical applications of SNAs in various fields may become possible.
Using the Y type fiber, high efficiency fiber coupler and A1GaInP diode laser has developed a new diode laser therapy apparatus with the wavelength of 650nm. The output laser power from the fiber of the apparatus can reach more than 100mW. The fiber localizer of the apparatus is easy for orientation during the therapy and the output laser power is very stable and reliable. The apparatus has been widely used in about 20 hospitals, and has successfully cured more than 50,000 patients who suffered from various diseases, which mainly including cervical spondylosis, traumatic infection, skin bruise, sudden deafness, tympanitis, tinnitus, infantile rhinallergosis, rheumatism, rheumatoism, scapulohumeral periarthritis, asthma, temporomandibular joint disturbance, ulcer, eczema ani, postoperative crissal edema, and so on. The apparatus has also well performed in the application of haematococcus pluvialis's laser mutagenesis breeding.
The therapeutic effectiveness of laser-electromagnetism combined therapy in chronic prostatitis is studied. Four patients were treated by irradiating the prostate's correlative parts and acupoints with 650nm semiconductor laser and pulse electromagnetism respectively. Three of them were recovery and only one was ineffective. This demonstrates the feasibility of using laser-combined electromagnetism for assistant treatment on chronic prostatitis. A further study on combined therapy of chronic prostatitis using 810nm, 650nm semiconductor laser and pulse electromagnetic wave is also introduced.
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