Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal hormones over the menstrual cycle. Therefore, we assessed the responses to multiple experimental pain stimuli during the menstrual cycle and computed their correlations with the salivary concentrations of the gonadal hormones estrogen and testosterone. Methods: Twenty-four healthy and regularly menstruating women between 20 and 41 years old took part in the study. Detection thresholds (warmth, cold and electrical current) and pain thresholds (cold, heat, pressure and electrical current) were assessed on days 1, 4, 14 and 22 of the menstrual cycle. In each session, salivary samples were collected for the determination of the physiological estrogen 17β-estradiol, progesterone and testosterone. Progesterone was used exclusively to verify regular menstrual cycling. Results: Significant variations in pain thresholds for cold, pressure and electrical stimuli were observed over the menstrual cycle with the highest thresholds on day 22, except for the cold pain thresholds, which peaked on day 14. There were no such changes regarding heat pain and all the detection thresholds. The correlations separately computed for each of the 4 days between salivary estrogen as well as testosterone on the one hand and the detection or pain thresholds on the other hand failed to show significant levels, except for the coupling of testosterone and electrical pain thresholds on day 1. Conclusions: The pain thresholds for all the physical stressors increased after menstruation. The acrophases were located in the follicular (cold pain threshold) or in the luteal phase (pressure and electrical pain thresholds). The results of our correlation analyses indicate only minimal influences of the physiological levels of gonadal hormones on pain sensitivity in women.

Background: Migraine is a common headache disorder that can vary menstrually in women and has been linked to an impairment of endogenous pain inhibitory systems. One of these endogenous pain inhibitory systems, namely conditioned pain modulation (CPM; formerly diffuse noxious inhibitory controls-like), has been shown to be affected by the menstrual cycle. The aim of this study was to examine CPM over the menstrual cycle in migraineurs and healthy controls. Methods: Twenty healthy women and 32 female migraineurs were examined on days 1, 4, 14 and 22 of the menstrual cycle. Detection and pain thresholds for electrocutaneous stimuli were first assessed at baseline. Second, tonic heat stimuli were applied concurrently to the electrical stimuli, and the difference in electrical thresholds to baseline were analysed as indicating CPM inhibition. Results: Migraineurs revealed higher detection thresholds than the control group but similar pain thresholds for the electrical current. Likewise, pain sensitivity for tonic heat stimulation also did not differ between groups. With regard to our main hypotheses, we found that CPM inhibition neither differed between migraineurs and healthy volunteers nor varied over the menstrual cycle. Conclusions: Our findings suggest that CPM inhibition is not altered in female migraineurs; thus, it is questionable whether CPM really plays a role in the development of migraine or whether migraine leads to a dysfunctional CPM inhibition.

In this study, the use of OC intensified migraine (however only at the end of menstruation) however had no influence on detection and pain thresholds in migraineurs. Possible reasons for this dissociation will be discussed.

The Autism Diagnostic Observation Schedule (ADOS) is a semi-structured, standardized assessment designed for use in diagnostic evaluation of individuals with suspected autism spectrum disorder (ASD). The ADOS has been effective in categorizing children who definitely have autism or not, but has lower specificity and sometimes sensitivity for distinguishing children with milder ASDs. Revised ADOS algorithms have been recently developed. The goals of this study were to analyze the predictive validity of different ADOS algorithms for module 3, in particular for high-functioning autism spectrum disorder. The participants were 252 children and adolescents aged between four and 16 years, with a full-scale IQ above 70 (126 with a diagnosis of ASD, 126 with a heterogeneous non-spectrum diagnosis). As a main finding, sensitivity was substantially higher for the newly developed 'revised algorithm', both for autism versus non-spectrum, as well as for the broader ASD versus non-spectrum, using the higher cut-off. The strength of the original algorithm lies in its positive predictive power, while the revised algorithm shows weaknesses in specificity for non-autism ASD. As the ADOS is valid and reliable even for higher functioning ASD, the findings of the present study have been used to make recommendations regarding the best use of ADOS algorithms in a high-functioning sample.

Die Effektivität des Elterntrainings „Stepping Stones/Triple P” als ergänzende Behandlung von Kindern mit einer Autismus-Spektrum-Störung (ASS) wurde untersucht. Die Eltern von 13 Kindern mit ASS (neun Jungen, vier Mädchen) zwischen vier und zwölf Jahren (M=6.7 Jahre, SD=2.61) nahmen an der Studie teil. Das Training fand über einen Zeitraum von 14 Wochen mit acht Gruppensitzungen à zwei Stunden statt. Die Eltern wurden zum Prä- und Postzeitpunkt, sowie sechs Monate später bezüglich komorbider Verhaltensauffälligkeiten und dem Erziehungsverhalten befragt. Außerdem wurden die autistische Kernsymptomatik sowie die elterliche Belastung zum Prä- und Postzeitpunkt erhoben. Ein Teil der Eltern wurde zusätzlich als Eigenwarteliste-Kontrollgruppe erfasst. Durch das Elterntraining konnten die komorbiden Verhaltensauffälligkeiten der Kinder reduziert werden (d=.65), außerdem verbesserten sich die Erziehungsfertigkeiten (d=.97). Keine Veränderungen ergaben sich hinsichtlich der elterlichen Belastung und der autistischen Kernsymptomatik. Insgesamt zeigt sich das Elterntraining nach „Stepping Stones/Triple P” als sinnvolle begleitende Intervention in der Behandlung von Kindern mit einer ASS.

The elderly patients were underrepresented in outpatient psychotherapy, is returned in the clinical literature on the reluctance and skepticism of psychotherapists. In the study presented here, psychotherapists were asked how they perceive the elderly, the attitudes they have towards them and what factors it depends on how many older people a psychotherapist treats. Total confirmed that psychotherapists also create a very positive attitude towards older people of the day. Of particular impact in terms of how many older people treated a psychotherapist, have experience and knowledge in the age of psychotherapy. Overall, there are a number of references for arguing that the clinical field of treating the elderly gradually gains more contours.

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Die Behandlung älterer Patienten in Psychosomatischen Kliniken begann Anfang der 1990er Jahre. Die Behandlungszahlen sind bis heute nur allmählich angestiegen, dabei werden bevorzugt die »jungen Alten« behandelt, Hochaltrige hingegen nur selten stationär aufgenommen.