Background: TB patients are generally the most productive age group and suffer from chronic energy deficiency. Therefore, patients with TB requires a combination of chemotherapy and supplementary feeding as probiotics and zinc to boost the immune response and nutritional status.Objective: To analyze the effect of a combined of probiotics and zinc on the changes of hemoglobin, albumin level, and BMI.Method: This study is a quasi-experimental, randomized design with pre-post test control group involving 52 respondents. They were divided into two groups. The treatment group was given a combination of 1 capsule of probiotics (2 billion probiotics) and zinc 20 mg per day for 28 days. The analysis is paired t-test, independent t-test, Mann-Whitney, Pearson, Spearman, Covariance.Results: There was an increase in hemoglobin (p=0.01), albumin (p=0.01) and BMI (p=0.01). There is no difference between the two groups in the levels of hemoglobin parameter (p=0.21) and BMI (p=0.12), whereas there is a difference parameter albumin levels (p=0.01). The effectiveness of interventions is 4% for hemoglobin levels, 16% to albumin, and 1% for IMT.Conclusion: Probiotics and zinc for 28 days in patients with pulmonary tuberculosis may increase levels of hemoglobin, albumin, and BMI, but there is no significant difference in the changes of BMI. The most powerful influence of intervention effectiveness is on albumin.
ABSTRAK Latar Belakang: Pasien anak dengan kanker dapat mengalami stunting dan wasting secara bersamaan dan hal tersebut mempunyai efek negatif terhadap pasien. Namun, sedikit studi di Indonesia yang meneliti tentang stunting dan wasting pada pasien onkologi anak di Indonesia. Tujuan: Penelitian ini bertujuan untuk mengetahui faktor yang berkaitan dengan stunting dan wasting pada pasien anak dengan kanker. Metode: Studi retrospective cross-sectional dilaksanakan di RSUP Dr. Kariadi Semarang, dengan subyek pasien anak usia 1-5 tahun dengan kanker yang menjalani rawat inap selama tahun 2020-2022. Kejadian stunting menggunakan definisi tinggi badan berdasar usia < -2 SD, sedangkan wasting jika partisipan memiliki berat badan dibanding tinggi badan < -2 SD. Kategori usia, jenis kelamin, pekerjaan orang tua, usia orang tua, tempat tinggal, pembiayaan, asupan energi dan kategori kanker dianalisa bivariat dengan kejadian wasting dan stunting menggunakan chi-square dan multivariate dengan regresi logistik. Hasil: Dari 194 patients, 52.1 % laki-laki, dan 78.4 % berusia 2-5 tahun. Prevalensi stunting, wasting, dan kejadian stunting dan wasting secara bersama sebesar 31.4 %, 39.2 % dan 13.4 %. Pada analisa multivariat asupan energi kurang dari 75 % yang berhubungan dengan stunting dan wasting (OR = 2.75, 95 % CI = 1.14-6.58, p = 0.023). Kesimpulan: Faktor yang berkaitan dengan stunting dan wasting pada anak dengan kanker adalah asupan energi yang kurang dari 75 %. Kata kunci: Stunting, Wasting, Kanker, Onkologi, Anak
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