in the promoter region of TSGs (Yang et al., 2017). Abnormal regional hypermethylation of the 5′ region of several TSGs has been observed in HCC (Baylin et al., 2011). Down-regulation of a variety of TSGs expression because of abnormal hypermethylation in their promoter regions could play a critical role in liver tumorigenesis
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.