Many studies have shown that estrogen has a protective effect on premenopausal
women with metabolic disorders and non-alcoholic fatty liver disease. Estrogen
supplements may, at least in theory, prevent the development and progression of
NAFLD, while the possibility of inducing cancer limits its application in
practice. Phytoestrogen is extracted from plants, whose molecular structure and
biological activity are similar to those of mammals' estrogen,
therefore, could replace the role of estrogen and prevent the occurrence of
adverse reactions to estrogen. This article reviews the published literature
related to phytoestrogens and NAFLD as well as suggest the possible mechanisms
that may underlie the association between phytoestrogens and NAFLD. It is hoped
to provide basis for the treatment of NAFLD with phytoestrogen.