Clomiphene citrate (CC) is the agent of first choice in polycystic ovarian syndrome; however, anovulation problem does not resolve in a quarter of them. Thus, we investigated the value of anti-Müllerian hormone (AMH) in the prediction of ovarian response to CC in women with the polycystic ovarian syndrome (PCOS). This prospective cohort study included 90 anovulatory women with PCOS who were given 50 mg/d CC. The patients who ovulated occupied the group of responders and the patients who did not ovulate in three cycles included in the CC-resistant group. AMH levels of both groups were compared. p < .05 was considered statistically significant. Patients who ovulated had significantly lower serum AMH concentrations compared with the resistant group (p = .001). After analyzing the ROC curve, serum AMH concentration was found to be a useful predictor of CC resistance with the sensitivity of 66% and the specificity of 89%, when the threshold AMH concentration was >12.38 ng/ml in PCOS patients. In the present study, we revealed that the higher the AMH level the poorer the CC response would be in PCOS patients, therefore we recommend measuring the AMH levels of all PCOS patients before planning any ovulation induction treatment to achieve the desired success.
Aim: Fetal distress (FD) is mostly an important sign of fetal hypoxia. The hypothalamic-pituitary-adrenal axis is an important limb of acute stress response. Copeptin is a hormone of endogenous stress. The authors aimed to investigate whether the level of copeptin correlates with FD or not. Material and Methods:Twenty-four pregnant women and their babies with the diagnosis of FD confirmed by category III fetal heart rate (FHR) pattern were compared with 20 uncomplicated pregnant women and their babies who were delivered by elective cesarean section. Results: The mean maternal serum copeptin level showed no significant difference between the mothers of control group and the mothers of FD group (p > 0.05). The mean umbilical cord serum copeptin level showed no significant difference between the groups (p > 0.05). Conclusion: The authors revealed that copeptin is not correlated with the presence of FD, thus further studies are needed to discover new biomarkers.
Key Clinical MessageThe “rapid‐onset” cervical carcinoma is described as the diagnosis of invasive cervical carcinoma within 3 years of a “normal” Pap smear and it is a rare entity. In our case, we aimed to draw attention toward rapid progression of these endocervical adenocarcinomas to macroscopic sizes.
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