The correlation of maternal serum and cord blood copeptin levels with intrapartum fetal distress

Abstract

Aim: Fetal distress (FD) is mostly an important sign of fetal hypoxia. The hypothalamic-pituitary-adrenal axis is an important limb of acute stress response. Copeptin is a hormone of endogenous stress. The authors aimed to investigate whether the level of copeptin correlates with FD or not. Material and Methods:Twenty-four pregnant women and their babies with the diagnosis of FD confirmed by category III fetal heart rate (FHR) pattern were compared with 20 uncomplicated pregnant women and their babies who were delivered by elective cesarean section. Results: The mean maternal serum copeptin level showed no significant difference between the mothers of control group and the mothers of FD group (p > 0.05). The mean umbilical cord serum copeptin level showed no significant difference between the groups (p > 0.05). Conclusion: The authors revealed that copeptin is not correlated with the presence of FD, thus further studies are needed to discover new biomarkers.

[Retracted] Clinical Significance and Correlation Decomposition of Cord Blood NO, Activin A Levels, and MCA/UA with Fetal Distress

“…Neonatal asphyxia caused by persistent fetal distress is one of the main causes of perinatal death and can be complicated by various systemic diseases. Essentially, it may be complicated by various systemic diseases, especially affecting the cardiovascular system and the central nervous system and can cause permanent neurological consequences after childbirth, threatening not only perinatal life and future quality of life but also a burden on families and society [ 1 , 2 ]. Although the causes of neonatal asphyxia are relatively clear, some unexplained or chronic intrauterine fetal hypoxia-induced causes of neonatal asphyxia are currently at an unknown stage [ 3 ].…”

The Mother–Child Dyad Adipokine Pattern: A Review of Current Knowledge

“…The magnitude of differences in the measured concentrations for particular adipokines was variable. Namely, the values reported by various research teams for resistin [ 113 , 124 ], ghrelin [ 121 , 139 ], and nesfatin-1 [ 140 , 141 ] show a 2- to 9-fold variation in magnitude, while for adiponectin [ 113 , 116 ], leptin [ 119 , 121 ], visfatin [ 113 , 122 ], chemerin [ 146 , 147 ], apelin [ 141 , 148 ], adropin [ 151 , 152 ], copeptin [ 130 , 155 ], and omentin [ 156 , 157 ], they is a 20- to 50-fold variation in magnitude, and for leptin, an 80-fold variation in magnitude. The values presented for irisin are extremely variable, namely from 12 to 7740 ng/mL, with a 645-fold variation in magnitude [ 127 , 128 , 131 , 136 , 137 ].…”

“…The analysis concerning the copeptin level in maternal–infant dyads is incomplete and includes five reports which present the data for two different biological fluids only [ 130 , 133 , 153 , 154 , 155 ] ( Table 3 ).…”

“…Ulu and coworkers [ 155 ] investigated the copeptin level in maternal and cord serum in relation to fetal distress. The copeptin levels for both were at a similar level regardless of fetal status: for the intrapartum fetal distress group, maternal was 9.5 ± 2.0 ng/mL and cord was 8.8 ± 1.4 ng/mL; and for the control cohort, maternal was 9.3 ± 0.8 ng/mL and cord was 8.0 ± 4.4 ng/mL.…”

“…The copeptin levels for both were at a similar level regardless of fetal status: for the intrapartum fetal distress group, maternal was 9.5 ± 2.0 ng/mL and cord was 8.8 ± 1.4 ng/mL; and for the control cohort, maternal was 9.3 ± 0.8 ng/mL and cord was 8.0 ± 4.4 ng/mL. Moreover, a positive correlation between the maternal and cord copeptin levels, but not with birth weight, was detected [ 155 ].…”