Predictions for the transmission of genetic traits along to generations are an important process for patients, their family and genetic counseling. For this purpose, Bayesian analysis in which one can include a priori knowledge taking into account all relevant information into the problem could be a useful tool to examine how disease forecasting affects its probability so that it provides a more straightforward interpretation of predictions. Therefore, we investigate here transmissions of autosomal recessive diseases along to generations within Bayesian framework. In order to do that we develop a computer code that is useful to facilitate genetic transition matrices to forecast predictions of probabilities of transmission of genetic traits by using Mathematica software, well known as an algebraic manipulation language. Furthermore, the symbolic implementation of the code is applied for the cystic fibrosis disease forecasting in humans genetics. All results show that Bayesian analysis plays a central role of prediction for probabilities of transmissions of genetic traits along generations for cystic fibrosis disease or other autosomal recessive disorders.
In this paper, we studied Bayesian analysis proposed by Bretthorst[6] for a general signal model equation and combined it with a simulated annealing (SA) algorithm to obtain a global maximum of a posterior probability density function (PDF) for frequencies. Thus, this analysis offers different approach to finding parameter values through a directed, but random, search of the parameter space. For this purpose, we developed a Mathematica code of this Bayesian approach together with SA and used it for recovering sinusoids from noisy data. Simulations results support its effectiveness.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.