The length of the necrosis and renal insufficiency are the primary factors that result in a poor outcome in AMI patients. Prompt diagnostic evaluation and early therapeutic interventions may help to prevent the development of these fatal predictors.
We want to emphasize that in experienced centers percutaneous closure of PDA can be an alternative to surgery even in the extremely low birth weight babies.
In the experimental colitis model established by using DSS, treatment with quercitrin resulted in a histopathological improvement and reduction in biochemical parameters, inflammation and in bacterial translocation (p < 0.05).
Objective: In this experimental study, it was aimed to assess the effects of erythropoietin (EPO) on bacterial translocation in a rat model of colitis. Material and Methods: The rats were randomly assigned into control, colitis and EPO-treated groups (n= 8 in each group). Saline solution (NS) was administered to control rats via rectal route. A trinitrobenzene sulfonic acid and ethanol mixture (TNBS-E) was used to induce colitis in the experiment groups. No treatment was administered to colitis group after induction. Starting at one day after induction of colitis with TNBS-E, EPO (1000 IU/kg) was administered subcutaneously for three days to the rats in the EPO-treated group. Colonic inflammation was assessed by gross and microscopic examination on day five. Blood samples were obtained to evaluate bacterial translocation while hepatic, mesenteric tissue samples and mesenteric lymph node (MLN) samples were collected for tissue culture. Tissue myeloperoxidase (MPO) levels, and tumor necrosis factor alpha (TNF-α) and endotoxin levels in the sera were studied. Results: Significant gross and microscopic differences were found in the comparison between colitis and EPO-treated groups (p< 0.05). MPO level was significantly lower when compared to the colitis group (p< 0.05). Serum TNF-α and plasma endotoxin levels were significantly lower in the EPO-treated group than the colitis group (p< 0.05). Bacterial translocation was lower in the liver, spleen, MLNs and systemic blood in the EPO-treated group when compared to the colitis group (p< 0.05). Conclusion: In TNBS-E-induced rat model of colitis, EPO significantly decreased inflammation and bacterial translocation based on histopathological, biochemical and microbiological parameters.
A 12-year-old male patient was admitted to the emergency department due to abdominal pain since 2 days. We discovered that the abdominal pain was initially widespread in the abdomen and gradually dispersed to the lower left side. There was no nausea, vomiting, and diarrhea in the patient anamnesis. Physical examination was sensitivity and rebound was positive in the left lower quadrant of abdomen. Laboratory findings revealed leukocytosis in the analysis of the whole blood count (18,000/ mm 3), and his serum biochemical values were normal. Leukocytes and erythrocytes were absent in the urine test. The patient underwent an abdominal ultrasound for the diagnosis of abdominal pain, and as a result, a "target sign" was seen in the left lower ABSTRACT Introduction: Acute appendicitis is one of the most commonly diagnosed surgical diseases in children with emergency abdominal pain. Atypical localized appendicitis is rare and difficult so we can see delay in diagnosis. Malrotation anomaly is also a cause of left-sided appendicitis. Herein, we present a rare case of acute appendicitis in the left lower quadrant with malrotation anomaly. Case Report: A 12-year-old male patient was admitted to the emergency department due to abdominal pain since 2 days. We discovered that the abdominal pain was initially widespread in the abdomen and gradually dispersed to the lower left side. Medical examination and radiological assessment were conducted, and a diagnosis of acute appendicitis in left lower quadrant was made. The patient subsequently underwent surgery and was discharged on the second postoperative day. Conclusion: There are many causes of left lower quadrant pain in the abdomen. In cases with suspected findings on physical examination, imaging methods can be used to diagnose rare incidents.
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