We used real-time LDI to study regional variations in microcirculatory perfusion in healthy candidates to establish a new methodology for global perfusion body mapping that is based on intra-individual perfusion index ratios. Our study included 74 (37 female) healthy volunteers aged between 22 and 30 years (mean 24.49). Imaging was performed using a recent microcirculation-imaging camera (EasyLDI) for different body regions of each volunteer. The perfusion values were reported in Arbitrary Perfusion Units (APU). The relative perfusion indexes for each candidate's body region were then obtained by normalization with the perfusion value of the forehead. Basic parameters such as weight, height, and blood pressure were also measured and analyzed. The highest mean perfusion value was reported in the forehead area (259.21 APU). Mean perfusion in the measured parts of the body correlated positively with mean forehead value, while there was no significant correlation between forehead blood perfusion values and room temperature, BMI, systolic blood pressure and diastolic blood pressure (p = 0.420, 0.623, 0.488, 0.099, respectively). Analysis of the data showed that perfusion indexes were not significantly different between male and female volunteers except for the ventral upper arm area (p = .001). LDI is a non-invasive, fast technique that opens several avenues for clinical applications. The mean perfusion indexes are useful in clinical practice for monitoring patients before and after surgical interventions. Perfusion values can be predicted for different body parts for patients only by taking the forehead perfusion value and using the perfusion index ratios to obtain expected normative perfusion values.
(deutsch): Die Glaukome gehen mit einem Untergang von retinalen Ganglienzellen und deren Axonen einher, welche sich vornehmlich in der Netzhaut befinden. Die Vitreoretinale- und die Glaukomchirurgie überschneiden sich bei bestimmten Krankheitsbildern in einem nicht geringen Ausmaß. Ziel des vorliegenden Übersichtsartikels ist es diese Krankheitsbilder darzustellen und Behandlungsstrategien und die jeweiligen Wirkungsweisen gesammelt aufzuzeigen. Im Rahmen des vorliegenden Artikels werden die Themen malignes Glaukom / aqueous misdirection syndrome, Netzhautchirurgie bei Aderhautamotio und expulsiver Aderhautblutung, postoperative Blebitis und Endophthalmitis nach Glaukomoperation und Vitrektomie nach Glaukomoperationen zusammen beschrieben und die bestehenden Therapiepfade beim Management von auftretenden Komplikationen aufgezeigt. Insgesamt sind die Bereiche Glaukom- und Netzhaut-Glaskörperchirurgie eng miteinander verbunden. Kollegen beider Subspezialitäten sollten Kenntnisse über diese sie beide betreffenden Krankheitsbilder haben. Abstract (englisch): Glaucoma is associated with the demise of retinal ganglion cells and their axons, which are primarily located in the retina. Vitreiretinal and glaucoma surgery overlap to a not inconsiderable extent in certain diseases. The aim of this overview article is to present these diseases and to highlight treatment strategies and the respective modes of action in a collective manner. Within the scope of this article, the topics of malignant glaucoma / aqueous misdirection syndrome, retinal surgery for choroidal detachment and expulsive choroidal hemorrhage, postoperative blebitis and endophthalmitis after glaucoma surgery and vitrectomy after glaucoma surgery are described together and the existing therapeutic paths for the management of complications are shown. The areas of glaucoma and vitreoretinal surgery are tightly linked. Colleagues from both subspecialties should be familiar with a certain overview of diseases concerning both subject areas.
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