Relative indexes of cutaneous blood perfusion measured by real-time laser Doppler imaging (LDI) in healthy volunteers

Abstract

We used real-time LDI to study regional variations in microcirculatory perfusion in healthy candidates to establish a new methodology for global perfusion body mapping that is based on intra-individual perfusion index ratios. Our study included 74 (37 female) healthy volunteers aged between 22 and 30 years (mean 24.49). Imaging was performed using a recent microcirculation-imaging camera (EasyLDI) for different body regions of each volunteer. The perfusion values were reported in Arbitrary Perfusion Units (APU). The relative perfusion indexes for each candidate's body region were then obtained by normalization with the perfusion value of the forehead. Basic parameters such as weight, height, and blood pressure were also measured and analyzed. The highest mean perfusion value was reported in the forehead area (259.21 APU). Mean perfusion in the measured parts of the body correlated positively with mean forehead value, while there was no significant correlation between forehead blood perfusion values and room temperature, BMI, systolic blood pressure and diastolic blood pressure (p = 0.420, 0.623, 0.488, 0.099, respectively). Analysis of the data showed that perfusion indexes were not significantly different between male and female volunteers except for the ventral upper arm area (p = .001). LDI is a non-invasive, fast technique that opens several avenues for clinical applications. The mean perfusion indexes are useful in clinical practice for monitoring patients before and after surgical interventions. Perfusion values can be predicted for different body parts for patients only by taking the forehead perfusion value and using the perfusion index ratios to obtain expected normative perfusion values.

Fundamental supply of skin blood flow in the Chinese Han population: Measurements by a full‐field laser perfusion imager

“…Our study confirmed that blood flow in different cutaneous regions varied . Face and fingertips have higher perfusion values, especially eyelid and lips, which is consistent to the conclusion of Tur.…”

“…There was also no significant correlation between skin perfusion values and BMI after adjustment for age and sex in our study, which agrees with S. Morteza's conclusion . Microcirculatory dysfunction has been proposed to be an additional mechanism relating obesity through insulin resistance, and reduced capillary blood flow may contribute to the development of insulin resistance in muscle and other organs …”

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

“…Baseline skin blood flow is highly variable and changes according to the body part . We recently extensively reviewed the mechanisms of tests used to challenge the skin .…”

Laser doppler imaging as additional monitoring after digital replanting: A prospective study

“…A special camera recorded 20,000 images per second to sample the frequency spectrum. These images will be analyzed and compressed, resulting in perfusion, concentration, and speed information of the monitored tissue (Seyed Jafari et al, ).…”

“…This study aimed to determine the applicability of LDI‐devices, as a contactless, non‐invasive and simple to use high speed camera, to visualize microcirculation in real‐time in the post‐operative monitoring of digital replantation, in comparison to traditional clinical evaluation and temperature‐monitoring. The advantages and disadvantages of these procedures are assessed (Seyed Jafari, Schawkat, Van De Ville, & Shafighi, ).…”