OBJECTIVE: To describe the expression of integrins in the epithelium of oral hairy leukoplakia (HL) and compare to that of normal lateral tongue epithelium. MATERIALS AND METHODS: Immunohistochemistry to identify integrins (α2, a α5, α6, αv, β1) was performed, using a standard biotin‐streptavidin‐peroxidase technique on five clinically and histologically confirmed frozen biopsy specimens of HL and five normal lateral tongue control tissues. RESULTS: Expression of integrins α2, α3, α6, αv, β1 was seen both in HL epithelium and in normal control tissue.α5 expression was not seen in HL or in control tissue epithelium.α2 and α3 were expressed mainly in the basal and suprabasal layers; α6 expression was most intense on the basal surface of the basal cells, αv was expressed in the basal and suprabasal layers with more expression seen in the higher differentiated cell layers than the other integrins.β1 expression was seen in the basal and suprabasal layers only. No apparent difference between HL and normal oral mucosa was noted in the staining pattern of the various integrins. CONCLUSION: Integrins α2, α3, α6, αv, β1 are expressed in HL and the expression pattern is not different from that of normal oral mucosa.α5 is not expressed in HL or in normal oral epithelium.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.