Aim: The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials & methods: Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressure homogenization technique. Carbopol 940 was added as a gelling agent. Results & conclusion: The composition of optimized NE consist of labrafil along with triacetin as oil, tween 80 and cremophor EL in combination as a surfactant and transcutol HP along with PEG 400 and ethanol as cosurfactant. The droplet size of the NE was 141.1 ± 3.65 nm, with low polydispersity index and negative zeta potential. The aceclofenac–nanoemulgel was developed using carbopol 940 and exhibited excellent permeation in comparison to the marketed sample.
Background:
3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a
prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each
patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the
patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine.
3D printing technology is getting more consideration in new medicine formulation development as a modern
and better alternative to control many challenges associated with conventional medicinal products. There are
many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance,
accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved
the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology.
Methods:
This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes
can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to
provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional
to a novel drug delivery system.
Results:
It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise
spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion
and delivery of controlled drugs acts as a pivotal role.
Conclusion:
3D printing technology has an extraordinary ability to provide elasticity in the manufacturing
and designing of composite products that can be utilized in programmable and personalized medicine. Personalized
medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human
being which is associated with unsuitable drug dose.
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