Pharmaceutical Product Development Exploiting 3D Printing Technology: Conventional to Novel Drug Delivery System

Abstract

Background: 3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. There are many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance, accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology. Methods: This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional to a novel drug delivery system. Results: It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion and delivery of controlled drugs acts as a pivotal role. Conclusion: 3D printing technology has an extraordinary ability to provide elasticity in the manufacturing and designing of composite products that can be utilized in programmable and personalized medicine. Personalized medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human being which is associated with unsuitable drug dose.

Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

“…3D printing of cells (bioprinting) also holds promise for patient-specific tissue fabrication as a regeneration therapy. 7,8) The contribution of 3D printing technology to personalized medical therapy is thus clearly expanding.…”

“…New pharmaceutical applications of 3D printing technology are increasing following the U.S. Food and Drug Administration approval of the manufacturing of a 3D printed tablet (SPRITAM) in August 2015. 9,10) This orodispersible tablet is manufactured in bulk using a powder-based 3D printer and ZipDose technology. Other types of 3D printers using various printer materials have been studied to explore novel applications of 3D printed pharmaceuticals.…”

The impact of 3D-printed LAY-FOMM 40 and LAY-FOMM 60 on L929 cells and human oral fibroblasts

“…In this way, FDM technology can be used to produce materials with macro-scale to the nanoscale internal geometrical characteristics [43]. The first 3D-printed tablet (Spritam®) has met the FDA requirements, claiming the commercial vitality of FMD technique [41]. Another field where LAY-FOMM can find application is the manufacture of 3D-printed masks with pore size ranging from 16.90 to 146.60 μm [44] as additive manufacturing gives the opportunity to manipulate the pore size by changing the printer settings [45].…”

3D Printing of Mini Tablets for Pediatric Use

“…Research in the field of 3D printing in recent years has shown how diverse the areas of application of this manufacturing technology are, particularly in the pharmaceutical field. Since the approval of the first oral 3D-printed dosage form Spritam in 2015, many other studies have been conducted regarding the applicability of 3D printing for the production of a wide variety of dosage forms [1][2][3]. Among all the additive manufacturing techniques that belong to the field of 3D printing, fused deposition modeling (FDM) is the most widely used method for oral dosage forms [1][2][3][4][5][6].…”