Background: On patient quality of life, stent-associated symptoms can have a significant impact. Related to indwelling ureteral stents, hematuria, urgency, frequency, dysuria, and both bladder and flank pain are the most prevalent symptoms. Among them low back pain and irritative lower urinary tract symptoms and are more frequent. Because of its importance stent is being kept in situ with varieties of medication despite the stent related symptoms. To relief these symptoms like Tamsulosin, Solifenacin, Alphazosin etc., several alpha-adrenergic blocker and antimuscarinic drugs are used. Tamsulosin and Solifenacin both are not costly as use daily single dose. So combination of Tamsulosin and Solifenacin cost effective and may act as a reliever of stent related symptoms also. Objectives:To evaluate the effect of Tamsulosin and Solifenacin in relieving DJ stent related symptoms. Methodology:This prospective quassi experimental study was performed from November 2016 to April 2018. Patients who placed DJ stent after endoscopic stone management in the Department of Urology, Dhaka Medical College and Hospital recruited as study population. A total of 47 patients who were stented following ureteroscopic lithotripsy were included, allocated purposively into two groups. Group A (Tamsulosin) 24 and and Group B (Solifenacin) 23 patients were selected by purposive sampling technique according to inclusion and exclusion criteria for the study.