Background: Amyotrophic lateral sclerosis (ALS) disease which is also known as motor neuron disease (MND) or Lou Gehrig's disease, is causes the death of neurons controlling voluntary muscles. There may have association of serum uric acid, homocystine and ferritin with amyotrophic lateral sclerosis. But we have not enough data regarding these issues. The aim of this study was to evaluate the association of serum uric acid, homocystine and ferritin with amyotrophic lateral sclerosis.Methods: It was a case-control study conducted in the department of neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2010 to December 2011. Finalized 76 study people were divided into two equal groups containing 38 participants in each. In group I (case group) there were 38 patients with ALS and in group II (control group) there were 38 healthy people. The correlation of annual decline of ALS Functional Rating Scale-Revised (ALS-FRS) and forced vital capacity (FVC) were analyzed. Data were collected through pre-designed questioners and processed and analyzed by using SPSS version 11.5.Results: In this study the inverse correlation between serum uric acid and the annual decline of ALS-FRS in male, spearman rho correlation was -0.37 (p<0.01) and in female it was -0.78 (p<0.001). The inverse correlation between serum uric acid and the annual decline of FVC were in male, spearman rho correlation was -0.33 (p<0.05) and in female it was -0.39 (p<0.05). Inverse correlation between homocystine and the annual decline of ALS-FRS in male, spearman rho correlation was -0.42 (p<0.02) and in female, it was -0.64 (p<0.001). The inverse correlation between homocystine and the annual decline of FVC in male, spearman rho correlation was -0.41 (p<0.04) and in female, spearman rho correlation was -0.37 (p<0.05). The inverse correlation between serum ferritin and the annual decline of ALS-FRS in male, spearman rho correlation was 0.47 (p<0.01) and in female, spearman rho correlation was 0.76 (p<0.001). The inverse correlation between serum ferritin and the annual decline of FVC in male, spearman rho correlation was 0.49 (p<0.001) and in female, it was 0.71 (p<0.001).Conclusions: In most of the cases we found significant correlation of serum uric acid, serum homocystine and serum ferritin with amyotrophic lateral sclerosis (ALS). So all these components would be considered as some potential indicators or bio-markers of amyotrophic lateral sclerosis (ALS).
Background: Alzheimer’s disease is the most common cause of dementia. Uric acid is the end product of purine metabolism in humans and acts as a natural antioxidant, accounting up to 60% of the free radical scavenging activity in human blood to prevent free radicals induced oxidative cell injury. This study aimed to explore the association between serum uric acid level and cognitive impairment of Alzheimer’s disease patients compared to those of the non-demented age and sex matched controls.
Methods: This case control study was carried out in the department of neurology, BSMMU, Dhaka. Total 116 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 58 were grouped as case and rest 58 were control. All blood samples for serum uric acid were measured in the Biochemistry lab, Department of Biochemistry, BSMMU, Dhaka.
Results: A signiûcant reduction of serum uric acid levels in the AD group was found compared to those of the control group (4.35±1.59 Vs 6.89±1.68) which was statistically significant (p<0.001). We also found a positive correlation between serum uric acid levels with severity of Alzheimer’s disease (rp = 0.633, P<0.001). Among demographic variables educational qualification was statistically significant (p=0.006) in AD patients.
Conclusion: This study showed that oxidative injuries have an important role in the pathogenesis of AD. Higher levels of uric acid are associated with a decreased risk of dementia and better cognitive function later in life.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 83-88
We would like to report on a patient, a 52-year-old man with acute neurologic disorder, Guillain Barré Syndrome. He was successfully treated by intravenous immunoglobulin. The patient suffered from acute extensive anterior MI. 2 weeks after thrombolytic therapy with streptokinase, he developed GBS.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 103-104
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