Background: Rapid urease test and stool antigen test are both important diagnostic tools for the detection of Helicobacter pylori infection among peptic ulcer disease patients. Objective: The purpose of the present study was to compare the detection capacity of Helicobacter pylori infection with stool antigen test by comparing with rapid urease test among peptic ulcer disease patients. Methodology: This cross-sectional study was conducted in the Department of Clinical Pathology with the collaboration of Department of Gastroenterology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from October 2011 to September 2012 for a period of one year. All the clinically suspected Helicobactor pylori infected peptic ulcer patients attending in the Department of Gastroenterology at Bangabandhu Sheikh Mujib Medical University (BSMMU) for upper GI endoscopy were selected as study population. Stool antigen test for Helicobactor pylori specific antigen from stool sample was done with “ABON-One Step Helicobactor pylori antigen test device”. Endoscopy of upper GIT was performed in the Department of Gastroenterology. Biopsy taken during endoscopy for RUT. Rapid urease test (RUT) of endoscopic biopsy was performed. Result: A total 86 patients were recruited for this study. The mean (±SD) age was found 38.53(±10.40) years. Out of 86 patients 76 cases were SAT positive and 10 cases were negative. The sensitivity, specificity, positive predictive values and negative predictive values and accuracy of SAT with RUT are 85.53%, 90.0%, 98.48%, 45.0%, 86.05% respectively. The area under the curve was 0.283 with the lower and upper limits of 95% confidence interval of 0.133 and 0.432. This was statistically significant (p=0.003). Conclusion: In conclusion the stool antigen test is an effective method for the diagnosis of Helicobacter pylori infection. Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 161-164
H. pylori infection is an important medical problem in the whole world including Bangladesh. Diagnosis of the disease remains dormant. H. pylori are also related to gastric carcinoma. Early detection of H. pylori is very much important for diagnosis of the disease and successful treatment. The most reliable the non-invasive test is urea breath test. Still the test is not currently available in our country. So, it becomes necessary to validate another reliable modality of noninvasive test. To evaluate the relatively new monoclonal stool antigen test for identification of H. pylori infection in patients with peptic ulcer disease both before and after eradication therapy. And also to compare the stool antigen test with rapid urease test and histopathology of endoscopic biopsy. This quasi study was carried in a clinical pathology department of a tertiary level hospital. We included all patients with peptic ulcer disease those who were diagnosed by upper GIT endoscopy. Demographic variables and value of laboratory test including Stool antigen test, rapid urease test were studied in this study. Out of 86 patients with peptic ulcer disease, male was 65% and female was 35%. The mean age of the study subjects was 38.53 years. The true positive SAT was 63 (73.3%), false negative was 11.6%. The positive predictive values and accuracy of SAT with Histopathology were 95.45%, and 82.56% respectively. The result was statistically highly significant. Stool antigen test (SAT) is an early effective diagnostic tool like other methods for the diagnosis of H. pylori infection in our country. As the test is noninvasive, easy to perform, requiring short time and cost effective, this test will be popular to both patient and physician.
Purpose: To assess stool antigen test as an early effective diagnostic tool like other methods for the diagnosis of H. pylori infection in PUD patient. Patients and Methods: This cross-sectional study was carried in a clinical pathology department of a tertiary level hospital. We included all patients with peptic ulcer disease those who were diagnosed by upper GIT endoscopy. Demographic variables and value of laboratory test including Stool antigen test, rapid urease test was studied in this study. Result: A total of eighty-six patients were undergone for endoscopy after tested for Helicobactor pylori antigen in stool. Among 86 study subjects, Male was 56 (65%) and female was 30 (35%). The Mean (±SD) age was found 38.53(±10.40) years with range from 21 to above 60 years. Stool antigen test positive in 66 (66/86, 76.74%), negative in 20 (20/86, 23.3%). Rapid Urease Test positive in 76 (76/86, 88.4%), negative in 20 (20/86, 11.6%). Histopathology positive in 65 (65/86, 75.58%), negative in 21 (21/86, 24.42%). The result was statistically highly significant (P<0.001). Conclusion: Stool antigen test (SAT) is an early effective diagnostic tool like other methods for the diagnosis of H. pylori infection in our country. CBMJ 2020 July: Vol. 09 No. 02 P: 19-25
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