Background: Siddha Makardhwaja (SMD) is a classical Ayurvedic formulation markedly used as a traditional medicine in the rural population for various purposes such as stimulant, tonic, and rejuvenator.Methods: The present study is conducted to evaluate the effect of conventionally prepared SMD on the hematological parameters in experimental animals, for providing scientific data base for its logical use in clinical practice. Acute toxicity tests were conducted to determine the LD50 of the drug. To find out the effect of chronic administration of SMD on hematological parameters it was administered chronically to the male Sprague-Dawley rats at a dose of 40mg/kg for 28 days.Results: In this experiment the TC, DC, various erythrocytic parameters, platelet parameters, ESR were determined. The results of the studies are given below. There is an (13.41%) increase in the number of white blood cell count of the male rat, the increase though not significant yet it was prominent (p=0.257). There is an (15.87%) increase in the absolute count of Neutrophils of the male rat, the increase though not significant yet it was prominent (p=0.371). There is an (12.29%) increase in the absolute count of Lymphocytes of the male rat, the increase though not significant yet it was prominent (p=0.388). There is a statistically significant (p=0.035) increase in the number of platelet count of the male rat (11.13% increase). There is a (2.03%) decrease in the platelet volume distribution width of the male rat, the decrease though not significant yet it was noticeable (p=0.094). There is a statistically insignificant (p=0.619) (10.0%) increase in Erythrocyte sedimentation rate in blood from the male rat.Conclusions: As SMD decreases and increases abnormally on the hematological parameters in body of treated rats, so it should not be administered chronically at a higher dose. Further studies should be done by reducing the administered dose.
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<p>Growing energy demand has exacerbated the issue of energy security and caused us to necessitate the utilization of renewable resources. The best alternative for promoting generation in Bangladesh from renewable energy is solar photovoltaic technology. Grid-connected solar photovoltaic (PV) systems are becoming increasingly popular, considering solar potential and the recent cost of PV modules. This study proposes a grid-connected solar PV system with a net metering strategy using the Hybrid Optimization of Multiple Electric Renewables model. The HOMER model is used to evaluate raw data, to create a demand cycle using data from load surveys, and to find the best cost-effective configuration. A sensitivity analysis was also conducted to assess the impact of differences in radiation from the solar (4, 4.59, 4.65, 5 kWh/m<sup>2</sup>/day), PV capacity (0 kW, 100 kW, 200 kW, 300 kW, 350 kW, 400 kW, 420 kW), and grid prices ($0.107, $0.118, $0.14 per kWh) upon that optimum configuration. Outcomes reveal that combining 420 kW of PV with a 405-kW converter and connecting to the utility grid is the least expensive and ecologically healthy configuration of the system. The electricity generation cost is estimated to be 0.0725 dollars per kilowatt-hour, and the net present value is 1.83 million dollars with a payback period of 6.4 years based on the system's 20-year lifespan. Also, compared to the existing grid and diesel-generator system, the optimized system, with a renewable fraction of 31.10%, provides a reduction in carbon dioxide emissions of 191 tons and 1,028 tons, respectively, each year.</p>
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