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BackgroundAlzheimer’s disease (AD) is a progressively developing neurodegenerative disorder of the brain in the elderly people. Vanda roxburghii Rbr. root has been used traditionally in Bangladesh as tonic to brain and in the treatment of nervous system disorders including AD. Therefore, we aimed to investigate the cholinesterase inhibitory activities and antioxidant properties of the extracts from V. roxburghii.MethodsThe crude methanol extract from the roots of plant was sequentially fractionated with petroleum ether, chloroform, ethylacetate and water to yield their corresponding extracts. The extracts were assessed for acetylcholinesterase and butyrylcholinesterase inhibitory activity by modified Ellman method and antioxidant property by several assays including ferric reducing antioxidant power, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and hydroxyl radical, and inhibition of lipid peroxidation. Endogenous substances in the extracts were analyzed by the standard phytochemical methods and active compound was isolated by the chromatographic methods.ResultsChloroform extract was shown to demonstrate strong ferric-reducing antioxidant power and scavenging activity against DPPH and hydroxyl free radicals when compared with the other extracts and the reference standard catechin. The antioxidant effect was further verified by inhibition of lipid peroxidation in rat brain homogenates. Likewise, the chloroform extract exhibited the highest inhibition against both the acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 221.13 and 82.51 μg/ml, respectively. Phytochemical screening revealed a large amount of phenolics and flavonoids in the chloroform extract. Bioactivity guided separation techniques led to the isolation of a strong antioxidant from the chloroform extract and its structure was determined as gigantol on the basis of spectral studies.ConclusionThese results suggest that the chloroform extract of V. roxburghii, possibly due to its phenolic compounds, exert potential antioxidant and cholinesterase inhibitory activities, which may be useful in the treatment of AD.

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In the Bay of Bengal (BoB) area, landfalling Tropical Cyclones (TCs) often produce heavy rainfall that results in coastal flooding and causes enormous loss of life and property. However, the rainfall contribution of TCs in this area has not yet been systematically investigated. To fulfil this objective, firstly, this paper used TC best track data from the Indian Meteorological Department (IMD) to analyze TC activity in this area from 1998 to 2016 (January–December). It showed that on average there were 2.47 TCs per year generated in BoB. In 1998, 1999, 2000, 2005, 2008, 2009, 2010, 2013, and 2016 there were 3 or more TCs; while in 2001, 2004, 2011, 2012, and 2015, there was only 1 TC. On a monthly basis, the maximum TC activity was in May, October, and November, and the lowest TC activity was from January to April and in July. Rainfall data from the Tropical Rainfall Measurement Mission (TRMM) were used to estimate TC rainfall contribution (i.e., how much TC contributed to the total rainfall) on an interannual and monthly scale. The result showed that TCs accounted for around 8% of total overland rainfall during 1998–2016, and with a minimum of 1% in 2011 and a maximum of 34% in 1999. On the monthly basis, TCs’ limited rainfall contribution overland was found from January to April and in July (less than 14%), whereas the maximum TC rainfall contribution overland was in November and December (16%), May (15%), and October (14%). The probability density functions showed that, in a stronger TC, heavier rainfall accounted for more percentages. However, there was little correlation between TC rainfall contribution and TC intensity, because the TC rainfall contribution was also influenced by the TC rainfall area and frequency, and as well the occurrence of other rainfall systems.