Cutaneous tuberculosis (CTB), a rare manifestation of tuberculosis is one of the most challenging diagnoses to establish. Metastasic tuberculous abscess is a form of CTB which is characterized by cold abscesses on the patient's extremities or trunk without any involvement of underlying tissue. Here we report a case of 56-year-old Bangladeshi male with no previous history of TB, who presented with multiple abscesses over the body for 3 months. His diagnosis was confirmed on the basis of demonstration of Mycobacterium tuberculosis in the lesions by staining, PCR and culture. But no primary focus was found. After 1 month of anti-tubercular therapy, significant improvement was noted.
Drug-induced encephalopathy is a well-known side effect of many drugs. Isoniazid (INH), a first-line drug used in the treatment of tuberculosis, can cause encephalopathy in chronic kidney disease (CKD) patients though other isoniazid-related neurotoxicities are more commonly encountered in general population. We report isoniazid-induced encephalopathy in a female patient with CKD. She has been given rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine and prednisolone for the treatment of Pott's disease of cervical spine. The patient developed recurrent episodes of altered consciousness following the treatment. After exclusion of other causes, isoniazid-induced encephalopathy was suspected, which was further proved by symptomatic improvement after stopping isoniazid. How to cite this article: Alam MA, Uddin MJ, Khan AH, et al. Isoniazid-induced Encephalopathy in a Chronic Kidney Disease Patient: A Case Report. Bengal Physician Journal 2020;7(1):14–16.
Coronavirus disease-2019 (COVID-19) caused by the virus SARS CoV 2 is a major global health concern nowadays. Bangladesh is also confronting this highly transmissible disease with an exponentially rising number of cases across the country. This study was designed to observe the socio-demographic characteristics and clinical profile of COVID-19 patients in Bangladesh is still very scanty. In this cross-sectional observational study, a total of 662 COVID-19 positive patients were enrolled following selection criteria who attended the fever clinic at BSMMU. COVID-19 was found to be more prevalent in males as the male to female ratio was 2.5:1. The mean age was 37.50 ± 12.14. Most of them belong to the 31-40 year age group. Among the patients, 41.8% were obese. DM, hypertension and bronchial asthma are the most common comorbidities. The most frequent symptoms were fever 80.8%, cough 36%, anosmia 21.8% and runny nose 1.7%. Most of the patients sought healthcare for fever 77.6 %, cough 23.3 %, dysgeusia 13.3% and anosmia 21.7 %. About 86.6 % had no history of contact with positive cases. Most of them had been BCG vaccinated previously. BSMMU J 2021; 14(4): 114-120
Background: Eosinophilic Granulomatosis with Polyangiitis (EGPA), also known as Churg Strauss Syndrome, is an uncommon vasculitis associated with antineutrophil cytoplasmic antibody (ANCA). The hallmarks of the disease are asthma, eosinophilia and systemic vasculitis with varying degrees of neurological, cutaneous, cardiac, gastrointestinal and renal involvement. Diagnosisis often difficult since the symptoms are diverse,and a number of differentials need to be excluded. Case presentation: In this report,we describe a 60-year-old patient who presented with mononeuritis multiplex and painful skin rash. A history of late-onset asthma which was poorly controlled led us to suspect EGPA. Laboratory data showed, leukocytosis, eosinophilia(>10%), elevated ESR, CRP and IgE, normal chest Xray, positive Rheumatoid factor (RA) and perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) and evidence of extravascular eosinophils in histopathology report of skin biopsy.She was treated with Methylprednisolone and cyclophosphamide pulse therapy with a satisfactory response. Conclusion: Diagnosis of EGPA requires a combination of clinical and histopathological findings to meet the diagnostic criteria. A history of poorly controlled or late-onset asthma may guide us to the diagnosis that is frequently overlooked. Due to the wide heterogeneity of EGPA patients' phenotypes, sharp professional judgment is needed for early disease detection and treatment in order to avoid irreversible changes and poor outcomes.
Background: The COVID-19 pandemic has had a significant impact on the quality of life of individuals worldwide. The aim of this study was to assess the health-related quality of life (HRQOL) and its associated factors among COVID-19 patients discharged from hospital. Methods: This facility-based cross-sectional study was conducted among laboratory confirmed COVID-19 patients who were discharged from medicine department of Bangabandhu Sheikh Mujib Medical University and did their first-month follow-up from April to September 2021. A validated Bengali version of International Quality of Life Assessment, Short form – 36 (SF-36) questionnaire was used to assess the HRQOL status. Univariate and multivariate analyses were done for identifying factors associated with low HRQOL. Result: Out of 225 patients, the mean (standard deviation) age was 36.9 (14.2) years and four in every ten patients were women. Out of eight subgroups, almost all scored averagely 79 out of 100. Older age, rural residence and severe to critical disease was reported as factors for low physical and mental component summary of SF-36. Conclusion: COVID-19 patients with older age, rural residence and having severe to critical disease condition need to be addressed critically as they have a higher chance of having low HRQOL status after COVID-19 infection. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 91-95
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