Different species of mushrooms are being used increasingly for their nutritional and medicinal values. They are used in traditional medical practice in the treatment and prevention of diabetes, obesity, heart diesaes, hyperacidity, cancer and hypertension. This study was designed to see the effects of Pleurotus ostreatus on blood pressure and glycemic status of hypertensive diabetic male volunteers. The study was carried out in the National Mushroom development and Extension Center (NAMDEC) laboratory, Savar, Dhaka in collaboration with the Department of Pharmacy along with the Department of Biochemistry and Molecular Biology, Jahangirnagar University. A total of 27 hypertensive male volunteers suffering from type 2 diabetes mellitus with age range of 32 to 68 years, who were free from renal impairment and other known acute or chronic diseases were included in the study. Blood pressure, fasting plasma glucose, HbA1c and serum creatinine were measured before and after 3 months of regular intake of 3 grams mushroom powder capsule daily in in 3 divided doses. However they were allowed to continue the drugs they were taking already. The study showed that after 3 months of regular intake of Pleurotus ostreatus mushroom, both systolic and diastolic blood pressure decreased significantly (p<0.001). It was also observed that, Pleurotus ostreatus decreased fasting plasma glucose level significantly (p<0.001). Reduction of HbA1c % observed after 3 months of mushroom intake was found to be significant (p<0.001). But there was no significant change of plasma creatinine level (p>0.05) indicating Pleurotus ostreatus has no detrimental effect on renal system. From the study, it can be said that, Pleurotus ostreatus mushroom intake improves glycemic status and blood pressure control in diabetic hypertensive subjects. DOI: http://dx.doi.org/10.3329/bjmb.v6i1.13280 Bangladesh J Med Biochem 2013; 6(1): 5-10
Pre-eclampsia (PE) is considered as a major cause of maternal and fetal morbidity and mortality. When a pre-eclamptic woman develops associated hyperuricemia then fetal outcome may become worse. To observe the fetal outcome of hyperuricemic pre-eclamptic pregnancy in relation to normo-uricemic pre-eclamptic pregnancy in a hospital based comparative and cross-sectional study 62 pre-eclamptic patients were selected purposively. PE was diagnosed by hypertension and proteinuria. PE patients were divided into two groups by there serum uric acid level -Hyperuricemic & Normo-uricemic. Then fetal outcome markers (Stillbirth and low birth weight fetus) of the study groups were observed. In this study significant increased number of low birth weight fetuses was observed in babies born to hyperuricemic preeclamptic mothers in comparison with babies born to normo-uricemic pre-eclamptic mothers. According to the observation the estimation of serum uric acid may be considered in management of pre-eclamptic mothers, especially in lowering the rate of poor fetal outcome.
The comparative study has been designed to estimate serum magnesium (Mg) and potassium (K) in patients with acute myocardial infarction (AMI) and chronic ischemic heart disease (CIHD). A total 61 subjects were selected and were divided as group-I (30 subjects of AMI) and group-II (31 subjects of CIHD). Laboratory investigations were done for estimation of serum glucose and serum creatinine to exclude the diabetesmellitus and renal disease. Serum Mg was estimated by atomic absorption spectrophotometer and serum K by ion selective electrode. This study showed that Mg and K level in serum is significantly lower in patients with AMI than that of CIHD subjects. Findings of the study suggested that significantly reduced serum level of Mg and K persists in AMI than those of CIHD, which may be the cause of further cardiac complications. So it may be recommended for estimation and supplementation of Mg and K in both the cases of AMI and CIHD patients for better management.
Magnesium (Mg) and potassium (K) are the major intracellular cations whose presence in the serum are low, but minor changes of those may show a remarkable change in the various body functions specially in the heart. The study was designed to find out the correlation between serum Mg and K in acute myocardial infarction (AMI), chronic ischemic heart disease (CIHD) and normal healthy volunteers. It was carried out over a period of 18 months in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) in collaboration with Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital (SSMC & MH) and Atomic Energy Center, Dhaka. A total of 101 subjects were included in which 32 subjects were AMI, 34 CIHD and 35 normal healthy volunteers. Serum glucose and serum creatinine were estimated to exclude diabetes and renal dystrophies. Estimation of serum CK-MB and ECG tracing were done as diagnostic tools of AMI and to categories the subjects into various groups. Serum Mg was estimated by Atomic absorption spectrophotometer and serum K by Ion sensitive electrode. The present study shows that there is a strong positive correlation of serum Mg and K in AMI, CIHD and healthy control subjects (r = 0.566, p<0.01 level). So it is suggested to estimate and supplement both Mg and K in IHD patients for their better management. DOI: http://dx.doi.org/10.3329/bjmb.v3i2.13812 Bangladesh J Med Biochem 2010; 3(2): 50-56
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