BACKGROUNDIncidence of dengue fever is on rise in India. We investigated the characteristics of Mean Platelet Volume (MPV) and platelet distribution width (PDW) in various risk categories of dengue fever. MATERIALS AND METHODSIn this prospective two months pilot study, 100 cases of NS1 antigen and IgM ELISA positive dengue were included. Platelet count for risk categorisation, MPV and PDW values were recorded. Statistical analysis was done using ANOVA (Fisher's test). RESULTSThere were 77%, 18% and 5% cases in no, low and moderate risk categories, respectively. In no, low and moderate risk categories, mean MPV was 8.6, 9.6 and 10.7 (fL), respectively. In no, low and moderate risk categories mean PDW was 16.4, 17.03 and 16.9, respectively. Overall, there was positive correlation between MPV and PDW (p= 0.066; r= 0.185), as also in low risk category. In moderate risk group, there was a negative correlation between MPV and PDW (p= 0.201; r= -0.686).

Lymphoepithelial salivary gland cysts are rarely seen in autoimmune diseases particularly Sjogren syndrome as well as in HIV for which medical management is advocated. To study the morphology of these cysts, correlate with the disease process and assess the final outcome. Case series. Fine needle aspiration clinic. HIV-infected and autoimmune disease patients with lymphoepithelial cysts. Antiretroviral therapy for HIVpatients and anti-inflammatory drugs for Sjogren syndrome. Three HIV-infected patients (two children and one adult) and three middle aged female patients presented with parotid and submandibular cysts, two of which were bilateral along with submandibular (one each in the HIV and the autoimmune group). In the adult HIV-patient, the cyst was found at the inception of the disease while the other pediatric HIV-patients just crossed a decade. Of the other three cases of Sjogren syndrome, two were primary and one, secondary to rheumatoid arthritis. All the cysts regressed completely with treatment of the respective diseases which was confirmed by ultrasonograms. Lymphoepithelial cysts are produced by release of serous secretion by the acinar and ductal cells within the epithelial islands in the process of their destruction. Possibly, antibody mediated increased secretion in the initial stages also plays a role. Lymphoepithelial cysts of HIV patients may occur in the course of treatment, not necessarily in the beginning, though it resolves spontaneously. Lymphoepithelial cysts of primary or secondary Sjogren syndrome may be repressed sufficiently by antiinflammatory/immunosuppressant treatment.

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