Correlation of Mean Platelet Volume and Platelet Distribution Width in Risk Categories of Dengue Fever- A Pilot Study

Kumar, Nidhish; Swamy, Mayuri; Chakraborti, Shrijeet; Kini, Jyoti R.; Singh, Tanwi; Sahay, B. M.; Singh, Sharvani

doi:10.14260/jemds/2018/31

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…13,15,22 MPV patterns showed a range of 8.7 -13.2 but differed in others. 6,13,15,21,23 The average MPV was in accordance with few studies like Basher et al & Pritam Sewakdar et al 6,10,14 but varied in others like Gogaram et al 19,24,25 MPV patterns were similar to the study by Ishito et al thrombocytopenia patterns were in accordance with the same 3 but varied in others. 2,4 Our study showed a high MPV in increased proportion of thrombocytopenia cases in accordance with few 24,25 but differed in others 21 we had a predominance of high MPV associated with severe thrombocytopenia and high hematocrit as per the WHO criteria for severe dengue.…”

Section: Discussionsupporting

confidence: 86%

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Joshi¹,

Sathyavathi²,

Gayathri³

et al. 2020

IJPO

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Dengue, endemic in India presents in mild to severe forms with or without bleeding. There is no specific treatment available till date hence severe dengue has to be recognized in early stages. Platelet counts are unreliable as they do not correlate with bleeding. Platelet indices have been studied for their utility as predictors of severity of the disease and aid in guide to transfusion therapy. Mean platelet volume is inexpensive and available with routine complete blood counts in hematology analyser. Its role as marker in diagnosis, prognosis and treatment of dengue has been investigated with platelet indices reports. To study MPV patterns, association with platelet counts and relevant laboratory parameters in dengue. The study was conducted over one month in the year 2016 in department of Hematology, Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 100 serologically proven dengue cases were analysed with data collected from the records in the departments of Hematology and Microbiology against patient’s unique hospital identification number. There was a predominance of young male patients. The range for MPV was 8.7 – 13.2 (average 10.95) with 35% normal and 65% high MPV cases. There was 48% cases with moderately severe / severe thrombocytopenia. 32% with increased hematocrit, 35% with leucopenia, 54% with significant atypical lymphocytosis and 42% with antibody pattern. There was an increased number of high MPV seen in severe thrombocytopenia, increased hematocrit significant atypical lymphocytosis and antibody pattern whereas normal pattern was noted in leucopenia. High MPV is a useful predictor of severe dengue platelet recovery and may guide in transfusion therapy.

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Section: Discussionsupporting

confidence: 86%

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Joshi¹,

Sathyavathi²,

Gayathri³

et al. 2020

IJPO

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“…Most of the guidelines for treatment of dengue advocated prophylactic platelet transfusion without hemorrhagic manifestations at platelet level 10,000-20,000/cu.mm [6]. Kumar, et al also marked patients with platelet count below 20,000/cu.mm as high risk patients [7].…”

Section: Resultsmentioning

confidence: 99%

Untitled

2019

Int J Trop Dis

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Background: Dengue fever is one of the most important emerging infectious diseases constituting important contribution in global burden of disease. Platelet transfusion is required in the patients when they develop Dengue Hemorrhagic Fever (DHF) or thrombocytopenia below 20,000/ cu.mm without hemorrhage. Serial platelet counts are used to monitor the patients. In this study we investigated whether Mean Platelet Volume (MPV) could be used as a tool to predict development of significant thrombocytopenia, DHF and Dengue Shock Syndrome (DSS). This may help in triage of high-risk patients and readiness of the care-givers for platelet transfusion when required. Methods: In this prospective study done in IIMSAR, Halides, 100 cases of dengue were included. In those patients who developed thrombocytopenia < 20,000/cu.mm, the MPVs prior to development of this significant thrombocytopenia, were compared with the mean of the MPVs of all the patients under the study. Statistical analysis was done using t-test. Results: On the previous day on which platelet count was < 20,000/cu.mm, mean MPV was significantly low (p value < 0.0001) compared to the mean of MPVs of all the patients. Conclusion: Serial MPV monitoring can be used to predict significant thrombocytopenia.

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“…Mature platelets become greater and more dynamic when platelet production decreases, and MPV levels rise [22]. Expanded MPV related to a consistent platelet count might show heling, however industriously brought MPV up related to proceeded with thrombocytopenia might demonstrate dynamic sickness causing platelet obliteration and the requirement for platelet transfusion [23]. Patients with haemorrhagic propensities have lower MPV levels joined with serious thrombocytopenia (20,000 platelets/Ul) could be an admonition indication of dengue fever and sign the requirement for red cell transfusion [24].…”

Section: Role Of Mean Platelet Volumementioning

confidence: 99%

Etiology of Dengue Fever

Khan

2022

OAJBS

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Since the 1950s, dengue fever has turned into a significant general wellbeing worry all over the planet. As indicated by the World Health Organization (WHO), 2.5 billion people have been presented to dengue fever and its ramifications. As indicated by a contemporary study, there are 390 million examples each year, with 96 million of those giving at minimum a few clinical manifestations. Cautioning signs were proposed as a pointer for dengue in 2009 by WHO. Patients with any warning signs ought to be conceded to a medical clinic for perception and therapy.

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Correlation of Mean Platelet Volume and Platelet Distribution Width in Risk Categories of Dengue Fever- A Pilot Study

Cited by 4 publications

References 11 publications

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

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Etiology of Dengue Fever

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