Regiospecific bromination and debromination reactions have been used to provide a synthetic route from camphor to optically active 8,10- and 9,10-disubstituted camphor derivatives.
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Preparation of 7-Ethoxy-3-hydroxy-6-methoxy-1-methyl-4-nitroisoquinoline.-A facile large-scale synthesis of the title isoquinoline (VII), which possesses both positive inotropic and systemic peripheral vasodilating activity, starting from commercially available phenylacetic acid (I) is given. -(BARTON, D. L.; FABIAN, A. C.; LAM, M. M.; STERBENZ, J. T.; J.
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