An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient. She had undergone cholecystectomy for gall stones some years earlier. There Reduced levels of albumin (3.2 g/dl) and haematocrit (35%) and raised levels of alpha-lproteinase-inhibitor (283 mg/dl) and C-reactive protein (5.7 mg/dl) indicated acute inflammation.
We describe here a standard protocol for the radiochemical assay of 5-aminolevulinate
synthase from 17-day chick embryo liver mitochondria and starved male rat liver
mitochondria. The assay is sensitive to at least 15 pmol of the δ-aminolevulinate produced
and can be adapted to suit most tissue types. A number of possible modifications to the
procedure are discussed.
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