Sedation of children who are undergoing EEG examinations is effective and safe. Complications are infrequent. The need for sedation can be decreased greatly by adequate preparation and by creating a less-threatening, child-friendly environment in which to perform the study.
A 9-month-old boy with migrating partial seizures of infancy due to a de novo KCNT1 mutation c.2278A.T (p.Ile760Phe) developed bluish discoloration of the hands, feet, and lips (figure) during a 9-month trial of quinidine (40 mg/kg/d; level 3.4 mg/mL).1 There was no exposure to other medications that cause pigmentary changes. Given minimal improvement in seizures and development, quinidine was stopped. Discoloration persisted at 3 months but markedly improved by the 6-month follow-up. Though common with other potassium channel blockers (ezogabine and quinine), such discoloration has only rarely been reported with quinidine, all in adults.2 Epileptologists should be aware of this potential complication of quinidine therapy. The patient developed bluish discoloration of the hands, feet, and lips in a similar distribution to that seen in ezogabinerelated skin discoloration. The sclerae were not affected. A dilated retinal examination has not been performed due to the severity of the patient's illness.NEUROIMAGES 2212
Les personnages romanesques du livre The Hours (et du film qui en a été tiré) illustrent à des degrés variables la nature et les effets de la personnalité as if (en tant qu’elle diffère du faux-self ), les origines de cet état dans la petite enfance, la vacuité et le manque d’authenticité relationnels qui la caractérisent, l’incapacité à donner et à recevoir de l’amour, les retraits illusoires auxquels ont recours les personnes qui en souffrent et les difficultés que présentent de tels patients en analyse.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.