In natural behavior animals actively gather information that is relevant for learning or actions, but the mechanisms of active sampling are rarely investigated. We tested parietal neurons involved in oculomotor control in a task in which monkeys made saccades to gather visual information before reporting a decision based on the information. We show that the neurons encode, before the saccade, the information gains (reduction in decision uncertainty) that the saccade was expected to bring, correlating with the monkeys’ efficiency in processing the information in the post-saccadic fixation. Informational sensitivity is independent of the neurons’ reward sensitivity, which is unreliable across task contexts, inconsistent with the view that the cells encode economic utility. Instead, we suggest that parietal cells are involved in implementing active sampling policies, showing uncertainty-dependent boosts of neural gain that facilitate the selection of relevant cues and the efficient use of the information delivered by these cues.

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Animals are intrinsically motivated to obtain information independently of instrumental incentives. This motivation depends on two factors: a desire to resolve uncertainty by gathering accurate information and a desire to obtain positively-valenced observations, which predict favorable rather than unfavorable outcomes. To understand the neural mechanisms, we recorded parietal cortical activity implicated in prioritizing stimuli for spatial attention and gaze, in a task in which monkeys were free (but not trained) to obtain information about probabilistic non-contingent rewards. We show that valence and uncertainty independently modulated parietal neuronal activity, and uncertainty but not reward-related enhancement consistently correlated with behavioral sensitivity. The findings suggest uncertainty-driven and valence-driven information demand depend on partially distinct pathways, with the former being consistently related to parietal responses and the latter depending on additional mechanisms implemented in downstream structures.