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We investigated the mode of growth of flat-topped mud volcanoes, through the study of three active edifices onshore Azerbaijan: they are the Bozdag-Guzdek, the Ayazakhtarma and the Akhtarma-Pashaly mud volcanoes. The three edifices are up to 80 m high and 3 km wide, and the recurrence time between eruptions from a few months to a few years. Surface changes during and between eruptions were documented by a combination of mapping from satellite pictures, repeated direct observation over five years and structural analysis. In addition, resistivity profiles and microgravity measurements were used to decipher their subsurface geometries. We interpret the flat-topped character of the mud volcanoes as the result of rapid "isostatic" readjustment of a brittle surface crust, < 1 m to tens of meters thick, overlying a ductile layer. The surface structure typically shows a concentric transition from an extensional regime in the vicinity of the emission center, to strike slip movements in a median ring, to a compressional regime with thrusts, and pop-up blocks or folds in the outer part of the plateau. Both the flat surface of these mud volcanoes and observed radial displacements of the surface, combined with the very low Bouguer anomaly of the Ayazakhtarma mud volcano, give arguments to propose that km-diameter, flat-topped mud volcanoes likely reflect the presence at a shallow depth (a few tens of meters?) of a large volume of soft mud. Rapid compaction at the surface forms a crust that moves away from a central feeding area, thereby transferring mud added at the center into lateral spreading, building a Coulomb prism all around the mud volcano and strongly limiting vertical buildup. Highlights ► We propose a new model of growth for flat-topped mud volcanoes fed from the center. ► Flat-topped MVs grow by radial expansion, making a concentric structural pattern. ► Fractures evolve from extensional in center to compressional at periphery. ► Gravity inversion shows a ca 300 m thick lowdensity lens below the surface. ► Soft mud in the lens limits vertical growth and flattens the MV by isostasy.

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The hypothalamus and pituitary regulate, amongst other functions, third order endocrine systems, and their volumes have been associated with normal and pathological outcomes. Yet, there are very few studies that examine their combined structural variations in vivo. This is due, in part, to their small size and a lack of comprehensive image segmentation protocols. In the current project we acquired high-resolution T1- (1mm isotropic) and T2-weighted (0.4mm in plane resolution) 3T magnetic resonance images (MRI) of the hypothalamus and pituitary gland, as well as salivary estradiol and testosterone from 31 (17M, 14F) young healthy adults. Women reported oral contraceptive use. Image preprocessing included non-uniformity correction, signal intensity normalization and standard stereotaxic space registration. We applied a comprehensive manual segmentation protocol of the whole hypothalamus, with detailed segmentation of the pituitary stalk, the anterior and posterior pituitary gland, and the posterior bright spot. We also propose a novel medial-lateral hypothalamic parcellation into medial preoptic, periventricular (PVN), and lateral hypothalamic regions. The protocol yielded good inter- (range: 0.78-0.92) and intra-rater (range: 0.79-0.94) Dice kappa overlap coefficients. We detected sex differences of the whole hypothalamus and each hemisphere, and a trend for the right preoptic region to be larger in males than in females, with a moderate effect size. Sex differences were maintained or enhanced when covarying for estradiol, but not when covarying for testosterone. In addition, testosterone was associated with the volume of the PVN, but only in women. In summary, these results suggest that there are morphometric differences at the level of the pituitary and hypothalamus that are likely driven by central regulation of gonadal hormones. The here described protocol allows the structural investigation of neuroendocrine effects in the central nervous system.