Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. Here, using a reverse translational approach, we show a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8–dependent mechanism. In a randomized controlled pancreatic cancer trial, CXCL8 increased under radiotherapy, and NK cell positively correlated with prolonged overall survival. Accordingly, NK cells preferentially infiltrated irradiated pancreatic tumors and exhibited CD56 dim -like cytotoxic transcriptomic states. In experimental models, NF-κB and mTOR orchestrated radiation-induced CXCL8 secretion from tumor cells with senescence features causing directional migration of CD56 dim NK cells, thus linking senescence-associated CXCL8 release to innate immune surveillance of human tumors. Moreover, combined high-dose radiotherapy and adoptive NK cell transfer improved tumor control over monotherapies in xenografted mice, suggesting NK cells combined with radiotherapy as a rational cancer treatment strategy.

Figure 1: Augmenting piano sheet music with harmonic fingerprint glyphs facilitates the identification of recurring harmonic patterns and the comparison of musical parts to understand differences in the note distribution. Here, an excerpt from Chopin's 'Grande Valse Brillante' is augmented with the fingerprints showing a recurring pattern in the first four glyphs. ABSTRACTCommon Music Notation (CMN) is the well-established foundation for the written communication of musical information, such as rhythm or harmony. CMN suffers from the complexity of its visual encoding and the need for extensive training to acquire proficiency and legibility. While alternative notations using additional visual variables (e.g., color to improve pitch identification) have been proposed, the community does not readily accept notation systems that vary widely from the CMN. Therefore, to support student musicians in understanding harmonic relationships, instead of replacing the CMN, we present a visualization technique that augments digital sheet music with a harmonic fingerprint glyph. Our design exploits the circle of fifths, a fundamental concept in music theory, as visual metaphor. By attaching such glyphs to each bar of a composition we provide additional information about the salient harmonic features available in a musical piece. We conducted a user study to analyze the performance of experts and non-experts in an identification and comparison task of recurring patterns. The evaluation shows that the harmonic fingerprint supports these tasks without the need for close-reading, as when compared to a not-annotated music sheet.

Star glyphs are a well-researched visualization technique to represent multi-dimensional data. They are often used in small multiple settings for a visual comparison of many data points. However, their overall visual appearance is strongly influenced by the ordering of dimensions. To this end, two orthogonal categories of layout strategies are proposed in the literature: order dimensions by similarity to get homogeneously shaped glyphs vs. order by dissimilarity to emphasize spikes and salient shapes. While there is evidence that salient shapes support clustering tasks, evaluation, and direct comparison of data-driven ordering strategies has not received much research attention. We contribute an empirical user study to evaluate the efficiency, effectiveness, and user confidence in visual clustering tasks using star glyphs. In comparison to similarity-based ordering, our results indicate that dissimilarity-based star glyph layouts support users better in clustering tasks, especially when clutter is present.

No abstract

Urban heat islands are local areas where the temperature is much higher than in the vicinity and are a modern phenomenon that occurs mainly in highly developed areas, such as large cities. This effect has a negative impact on energy management in buildings and also has a direct impact on human health, especially for elderly people. With the advent of volunteered geographic information from private weather station networks, more high resolution data is now available within cities to better analyze this effect. However, such data sets are large and have heterogeneous characteristics requiring visualinteractive applications to support further analysis. We use machine learning methods to predict urban heat islands occurrences and utilize temporal and spatio-temporal visualizations to contextualize the emergence of urban heat islands to comprehend the influencing causes and their effects. Subsequently, we demonstrate the analysis capabilities of our application by presenting two use cases.

No abstract

Generative text-to-image models (as exemplified by DALL-E, MidJourney, and Stable Diffusion) have recently made enormous technological leaps, demonstrating impressive results in many graphical domains—from logo design to digital painting and photographic composition. However, the quality of these results has led to existential crises in some fields of art, leading to questions about the role of human agency in the production of meaning in a graphical context. Such issues are central to visualization, and while these generative models have yet to be widely applied to visualization, it seems only a matter of time until their integration is manifest. Seeking to circumvent similar ponderous dilemmas, we attempt to understand the roles that generative models might play across visualization. We do so by constructing a framework that characterizes what these technologies offer at various stages of the visualization workflow, augmented and analyzed through semi-structured interviews with 21 experts from related domains. Throughthis work, we map the space of opportunities and risks that might arise in this intersection, identifying doomsday prophecies and delicious low-hanging fruits that are ripe for research.

The technical progress in the last decades makes photo and video recording devices omnipresent. This change has a significant impact, among others, on police work. It is no longer unusual that a myriad of digital data accumulates after a criminal act, which must be reviewed by criminal investigators to collect evidence or solve the crime. This paper presents the VICTORIA Interactive 4D Scene Reconstruction and Analysis Framework (“ISRA-4D” 1.0), an approach for the visual consolidation of heterogeneous video and image data in a 3D reconstruction of the corresponding environment. First, by reconstructing the environment in which the materials were created, a shared spatial context of all available materials is established. Second, all footage is spatially and temporally registered within this 3D reconstruction. Third, a visualization of the hereby created 4D reconstruction (3D scene + time) is provided, which can be analyzed interactively. Additional information on video and image content is also extracted and displayed and can be analyzed with supporting visualizations. The presented approach facilitates the process of filtering, annotating, analyzing, and getting an overview of large amounts of multimedia material. The framework is evaluated using four case studies which demonstrate its broad applicability. Furthermore, the framework allows the user to immerse themselves in the analysis by entering the scenario in virtual reality. This feature is qualitatively evaluated by means of interviews of criminal investigators and outlines potential benefits such as improved spatial understanding and the initiation of new fields of application.