Background: The objective was to determine whether an erector spinae plane (ESP) block could provide additional postoperative analgesic benefits compared with a transversus abdominis plane block. Methods: 78 patients were separated into two groups (n = 39 per group). Both groups received bilateral injections of 266 mg Exparel® (20 ml) and 60 ml of 0.125% bupivacaine. Patients undergoing a transversus abdominis plane block received these injections intraoperatively, while patients undergoing an ESP block received these preoperatively. Outcomes were measured based on scores in opioid usage; pain (visual analog scale) at rest and with movement; nausea; sedation and patient satisfaction. Results: There were no significant intergroup differences in any category (all scores had p > 0.05). Conclusion: No additional analgesic benefits were found using the ESP block procedure.
measurements, stopped-flow fluorescence and ITC. We are using pyrene labeled DNA, IkBa, or NF-kb to study the fluorescence changes occurring during the enhanced dissociation process. Our results show that IkBa increases the dissociation rate of the DNA from the NF-kB complex in a concentration-dependent manner and with high efficiency. We also repeated the experiments using different DNA chains and different mutants of IkBa. We are also studying IkBb, which appears to stabilize the NF-kB/DNA interaction. Both IkBa and IkBb are able to form NF-kB/DNA/IkB ternary complexes. The rates of association and dissociation of DNA to form the ternary complexes was also measured and compared to interpret the kinetics of the enhanced dissociation process.
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