The ontogenetic development of the enzymes alcohol dehydrogenase (ADH) and
acetaldehyde dehydrogenases (ALDH I and II) was followed in rats. ADH could be detected just
before birth and increased gradually to reach 82% of adult values at 47 days. ALDH I and II were
present from day 15 of gestation, increased rapidly at birth, and reached 80—90% adult values at
47 days. The ratio between ALDH and ADH activities decreased gradually during ontogenesis. The
relative subcellular distribution of all enzymes was identical before birth, 7 days after birth and in
adults. The placental activities of ADH and ALDH I and II were studied at 15 and 20 days of
pregnancy. ADH could not be detected in placentas. Low activities of ALDH I and II were present
in placentas studied at 15 days of gestation, and still lower activities were found in placenta at 20
days.
The influence of maternal ethanol drinking on the development of alcohol dehydrogenase and aldehyde dehydrogenases in the liver of the offspring was studied in Wistar rats. No statistically significant differences were found between the ethanol group and the control group.
Ke.v-words:Aldehyde dehydrogenase-alcohol dehydrogenase -development-maternal ethanol drinking-rats.Ethanol is metabolized in the liver mainly by the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are at least two different ALDH's in the rat liver (Tottmar el a/. 1973). ALDH I is located in the mitochondrion
After 5–10 h exposure in static bio‐assays first‐summer Salmo salar live in equilibrium with the ambient ethanol concentration of 117 mmol/1 at 10° and 16° C. At 4° C this equilibration is retarded and is not evident until after 24 h. A quantitative connection between ethanol oxidation (M) and body weight (W) in accordance with the general formula M = K × Wb seems to exist for young salmon at 16° C. From the present tests the numerical values of the constants K and b were estimated to be approximately 10.5 and ‐1.03 respectively. Changes in behaviour induced by ethanol and the influence of temperature upon the metabolism of ethanol are discussed briefly.
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