associated with SLE. Some cases of porphyria cutanea tarda induced by hydroxychloroquine have been reported. 3 In our case, urine studies did not demonstrate elevated levels of uroporphyrin. A bullous drug eruption may be due to naproxen-induced pseudoporphyria. 4 Other autoimmune bullous diseases have been reported, such as dermatitis herpetiformis, pemphigus vulgaris and pemphigus foliaceous, epidermolysis bullosa acquisita, linear IgA disease, erythema multiforme and bullous pemphigoid. [5][6][7][8][9] Nine cases of bullous pemphigoid occurring in patients with SLE have been reported, and in four cases, SLE preceded the onset of bullous pemphigoid by 2 months to 3 years (average: 13 months). The clinical presentation was typical in seven cases. DIF was done in eight of nine cases and showed deposition at the BMZ of IgG by itself in three and IgG with complement deposition in five. IIF was done in eight cases and showed circulating anti-BMZ antibodies in four. IIF on split skin was done in one case and revealed high titre (1 : 320) IgG deposition on the epidermal side. 9 However, immunoblot analysis was never done and it is uncertain whether the patients had bullous pemphigoid. Reports of bullous pemphigoid with other autoimmune diseases may be coincidental. 10,11 On the other hand, there is a whole host of autoimmune antibodies in SLE and one of them could be directed against the bullous pemphigoid antigen.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.