Eosinophilic fasciitis associated with low‐grade T‐cell lymphoma

Abstract

associated with SLE. Some cases of porphyria cutanea tarda induced by hydroxychloroquine have been reported. 3 In our case, urine studies did not demonstrate elevated levels of uroporphyrin. A bullous drug eruption may be due to naproxen-induced pseudoporphyria. 4 Other autoimmune bullous diseases have been reported, such as dermatitis herpetiformis, pemphigus vulgaris and pemphigus foliaceous, epidermolysis bullosa acquisita, linear IgA disease, erythema multiforme and bullous pemphigoid. [5][6][7][8][9] Nine cases of bullous pemphigoid occurring in patients with SLE have been reported, and in four cases, SLE preceded the onset of bullous pemphigoid by 2 months to 3 years (average: 13 months). The clinical presentation was typical in seven cases. DIF was done in eight of nine cases and showed deposition at the BMZ of IgG by itself in three and IgG with complement deposition in five. IIF was done in eight cases and showed circulating anti-BMZ antibodies in four. IIF on split skin was done in one case and revealed high titre (1 : 320) IgG deposition on the epidermal side. 9 However, immunoblot analysis was never done and it is uncertain whether the patients had bullous pemphigoid. Reports of bullous pemphigoid with other autoimmune diseases may be coincidental. 10,11 On the other hand, there is a whole host of autoimmune antibodies in SLE and one of them could be directed against the bullous pemphigoid antigen.

Scleroderma-like cutaneous syndromes

“…Of greatest potential concern is the development of hematologic abnormalities and myelodysplastic syndromes. Aplastic anemia, hemolytic anemia, thrombocytopenia, lymphoma, and B lymphocytic leukemia have been described in patients with EF [24,[28][29][30][31]. The pathogenesis of the hematologic complications of EF is unknown.…”

Severe Aplastic Anemia Associated With Eosinophilic Fasciitis

“…EF is sometimes associated with hematologic diseases, particularly with aplastic anemia (AA) (n = 19), 2 , 13 , 15 , 22 , 24 , 30 , 33 , 38 , 57 , 58 , 73 , 77 , 89 , 95 , 111 , 117 , 128 but also with T-cell lymphoma (n = 5), 27 , 36 , 65 , 72 , 83 cutaneous T-cell lymphoma (n = 1), 25 Hodgkin disease (n = 3), 84 , 90 , 98 myeloproliferative syndromes (n = 3), 61 , 75 , 85 myelomonocytic leukemia (n = 2), 75 , 85 chronic lymphocytic leukemia (n = 2), 12 , 75 multiple myeloma (n = 1), 68 and myeloblastic leukemia (n = 1), 90 and, less commonly, with solid tumors such as breast cancer (n = 5), 12 , 90 , 109 , 127 choroidal melanoma (n = 1), 125 colorectal cancer (n = 1), 94 and prostate cancer (n = 1). 90 Diffuse EF has also been reported in association with autoimmune disorders, such as Hashimoto thyroiditis (n = 6), 2 , 5 , 13 , 59 , 114 systemic lupus erythematosus (n = 4), 6 , 43 , 45 , 74 Crohn disease (n = 1), 82 Graves disease (n = 1), 114 glomerulonephritis (n = 1), 63 rheumatoid arthritis (n = 1), 81 type 1 diabetes (n = 1), 46 and autoimmune cytopenias, including autoimmune hemolytic anemia (n = 2), 5 , 44 immune thrombocytopenic purpura (n = 2), 5 , 111 amegakaryocytic thrombocyt...…”

Eosinophilic Fasciitis with Hypereosinophilia as the Initial Clinical Manifestation of Peripheral T-Cell Lymphoma, Not Otherwise Specified

“…While autoimmune disorders and certain hematological neoplasms, including myelomonocytic leukemia, chronic lymphocytic leukemia, and malignant lymphoma, are known to trigger the onset of EF ( 4), most cases are idiopathic with no clear association. Indeed, there are few reports of T-cell lymphoma preceded or accompanied by EF (6)(7)(8)(9). According to what reports do exist, EF can occur in association with T-cell lymphoma, at either the same time as the lymphoma or months or more in advance.…”