This study aimed to explore the relationship between happiness, self-efficacy and vocational capability of elementary school teachers of District 2 of Bandar Abbas. The research method was correlation-based and descriptive and the statistical population of the study consisted of 150 teachers of elementary school of District 2 of Bandar Abbas, and the volume of calculated sample was 108 students who were selected by available random sampling. In this study, three questionnaires were used: Schweitzer and Jerusalem's General Self-Efficacy Scale (1995), Oxford happiness and capability of Spritzer. According to the research findings, a significant and positive correlation was observed between self-efficacy with happiness and capability and between happiness and capability. The teachers' vocational capability has a strong and significant relationship with happiness and their self-efficacy.
Background: Gemini Curcumin (Gemini-Cur) is the latest nano formulation of curcumin with a significant apoptotic effect on cancer cell lines. Objective: This in vitro study aims to evaluate the apoptotic effects of Gemini-Cur toward MDA-MB-468 breast cancer cell lines and further the related mechanism of apoptosis. Methods: The cytotoxicity of Gemini-Cur toward MDA-MB-468 cell lines was tested using MTT assay. Furthermore, the expression ratio of Bax/Bcl-2 was evaluated by qRT-PCR. Consequently, the protein expression of Bax/Bcl-2, survivin, and caspase-3 was measured using western blotting. Results: Having treated MDA-MB-468 cell lines with Gemini-Cur, the IC50 values were found to be 44.44 and 31.63 µM at 24 and 48 h, respectively. Our findings showed that Gemini-Cur significantly suppresses cancerous cell proliferation in a time- and dose-dependent manner. Furthermore, the data revealed that curcumin nanoformulation induces apoptosis in MDA-MB-468 cells through modulation of the expression of Bax, Bcl-2, Survivin, and Caspase-3. Conclusion: The data of the current study propose that Gemini-Cur can be considered a promising candidate against triple-negative breast cancer.
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