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Introduction: Kidney transplantation was conducted in Mashhad University of Medical Sciences (MUMS) for more than 20 years. In recent years, about 160 kidney transplantation has been conducted here annually, that consisted of both cadaveric and living donor programs. Objectives: Since transplant outcomes have not been systematically monitored, we try by registration of this group of patients, donors and recipients, to analyze and share kidney transplantation outcomes. Patients and Methods: The kidney transplant registry program in Mashhad, Khorasan Razavi, started in 2016. This registry is a prospective, single center, longitudinal program, designed as a dynamic observational cohort that enrolls all transplant recipients and donors. Demographic data, etiology of chronic kidney disease and patient and graft survival were analyzed. Results: Baseline characteristics, treatment data, patient and donor condition before and after surgery, potential clinical events including hospitalization, co-morbidities and graft failure are all collected. Follow-up visits in recipients have been conducted in 1st, 3rd months and every year after operation. Data quality is ensured by automatic software validation and a manual data review process. Conclusion: By this system, it is easy to adhere to input. Likewise data is adequate for rapid statistical processing.