This is the first reported case of development of agranulocytosis induced by continuous intravenous infusion of a large quantity of ritodrine hydrochloride for tocolysis. It is suspected that the pathophysiological mechanism is a dose-related toxic reaction and a cell loss maturation process of myelocytes.
This paper describes a development of a robot scooter platform for intelligent personal mobility robot. Recently, a lot of personal mobility has been used by aged and handicapped people. Intelligent mobility robot provides safer and more convenient transfer service such as driving support and automatic transfer. It is necessary to develop a platform equipped with sensors, electronic devices and intelligent navigation functions. In this paper, we describe the hardware components and the con¿guration of the robot platform. The navigation system, including the functions of localization using grid map matching, path following, and obstacle avoidance, is implemented on the proposed robot platform. We also present the results of an open-¿eld experiment in Tsukuba Challenge 2010 and evaluate the proposed systems. The newly developed robot scooter successfully and autonomously ran a 1.1 km course in a normal living environment.Index Terms-Intelligent personal mobility robot, Mobility scooter, Navigation for public space.
Rats with bladder tumor induced by BBN were treated by intravesical instillation of 0.8 mg of (2"R)-4'-O-tetrahydropyranyladriamycin (THP) (9 rats) or adriamycin (ADM) (8 rats) dissolved in 0.2 ml of distilled water. Thirty minutes later, the bladder was removed surgically. Rats without the tumor received the same treatment of THP (8 rats) or ADM (9 rats). THP and ADM infiltrations to the normal bladder tissue and the tumor were estimated by the use of the photonic microscope system, since both drugs were known to emit characteristic fluorescence. It was found that infiltration of THP to the tumor tissue was more prominent in amounts and deeper than that of ADM, while smaller amounts of THP infiltrated into the normal mucosa compared to ADM. The fact might explain the clinical finding that THP instilled intravesically in half a concentration of ADM showed the same effect on the tumor as ADM. Subsequently, tissue concentrations of THP and ADM were estimated by high performance liquid chromatography. Either THP or ADM was instilled intravesically for 30 minutes to 6 rats with bladder tumor. Similarly, either THP or ADM was instilled in 5 rats without the tumors. Contrary to the result of the photonic microscope system, the tissue concentration of THP was not different from that of ADM not only in the tumor tissues but also in the normal bladder ones. Furthermore, the tissue concentration of both drugs in the normal bladder was higher than that in the bladder tumor.(ABSTRACT TRUNCATED AT 250 WORDS)
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