1,2-Epoxycyclohexane (1) was found to behave differently from propylene oxide (PO) in polymerization reactions with organozinc compounds as initiators. A chair-type complex, [Z~I-MP],~, is the only compound that shows high catalytic activity for both polymerization of 1 and PO, following an anionic coordination mechanism. On the other hand, the polymerization of 1 with ZnEt, or (EtZnOMe), as initiator proceeds according to a cationic mechanism. Cationic polymerization of 1 with ZnEt, has two modes of termination reaction resulting in the formation of terminal units containing vinyl ether and ally1 ether moieties. The initiation and propagation mechanism of 1 by [Zn-MP]22 is similar to that of PO, but chain transfer reaction takes place in the polymerization of 1 owing to the low stability of the growing chain end. By using [ZXI-MP],~ as initiator, it was possible to prepare a block copolymer consisting of an isotactic sequence of monomeric units of PO and a syndiotactic sequence of monomeric units of 1. 0 1990, HUthig & Wepf Verlag, Basel CCC 0025-1 16X/90/$03.00 P -
The alterations of the alkaline phosphatase (ALP) activity in the rat liver following bile duct ligation were investigated by electron microscopical techniques. Serum ALP activity reached the maximum at 24 hours after ligation and two isozymes of ALP, high molecular and low molecular one, appeared in the serum. Bile canaliculi became dilated at 48 hours after ligation and the microvilli were destructed and diminished in number. ALP activity was observed almost only on the bile canalicular membrane of the liver cells in the control. On the other hand, in the bile duct-ligated rat, the ALP activity on the canalicular membrane was markedly increased initially, then it appeared on the lateral membrane, and finally on the sinusoidal membrane also. It was not stainable on the canalicular membranes which lacked microvilli. The proposed pathway through which hepatic ALP enters the blood stream in bile duct-ligated rats is as follows: ALP, being synthesized in the microsomes of hepatocytes, is initially transferred to the bile canalicular membrane and diffused to lateral membrane through tight junction, reaches to sinusoidal membrane then released into the blood stream.
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