Acceleration of DNA synthesis in post-hepatectomized regenerating liver of normal rat by insulin and glucagon

Takatsuki, Katsuyoshi; Fujiwara, Kenji; Hayashi, Shigeki; Ota, Yasuhiko; Torii, Masao; Mishiro, Shunji; Ogata, Itsuro; Sakuma, Atsushi; Oka, Hiroshi; Oda, Tatsuya

doi:10.1016/0024-3205(81)90634-2

Cited by 25 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although agreement is not universal, several other types of experiments also support the likely importance of pancreatic hormones in the regenerative scheme (Starzl, 1980; Bucher and Strain, 1992). When insulin and glucagon are administered to normal, intact rats, there is no evidence of hepatic growth induction (Bucher and Swaffield, 1975), but in partially hepatectomized rats the rate of DNA synthesis is approximately doubled (Takatsuki et al, 1981;de Diego et al, 1986).…”

Section: Hormonesmentioning

confidence: 96%

Liver regeneration following partial hepatectomy: genes and metabolism

Bucher

Farmer

1998

Liver Growth and Repair

View full text Add to dashboard Cite

Section: Hormonesmentioning

confidence: 96%

Liver regeneration following partial hepatectomy: genes and metabolism

Bucher

Farmer

1998

Liver Growth and Repair

View full text Add to dashboard Cite

“…Glucagon exerts multiple physiologic functions in vivo, and has been implicated as a growth factor [7,8], Glucagon increases glomerular filtration rate in diabetic and normal individuals [12,13], an effect which is inde pendent from its positive inotropic action on myocar dium [14]. This hormone also causes a natriuresis and a calciuresis [15][16][17], Glucagon promoted renal growth in the intact animal with two kidneys, but had no measurable effect on DNA synthesis, as judged by in vivo thymidine uptake into renal DNA.…”

Section: Discussionmentioning

confidence: 99%

“…Glucagon has been implicated as a circulating growth factor in a variety of conditions. Por tal venous glucagon and insulin concentrations are im portant in the process of hepatic regeneration following partial hepatectomy [7], Glucagon also appears to play a key role in the process of renal cellular hypertrophy, a characteristic feature of the early stages of clinical and experimental diabetes mellitus [8,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Glucagon on Physiologic and Compensatory Renal Growth in the Rat

Logan

Lee²

1988

Horm Res

View full text Add to dashboard Cite

Glucagon has been implicated as a growth-promoting hormone in the kidneys of diabetic animals, but its role in the nondiabetic state is unknown. We evaluated the effect of subcutaneous glucagon administration on renal growth in intact rats with two kidneys and after 50% reduction in renal mass. The relative kidney weight was increased in intact rats treated with a glucagon infusion for 7 days (p < 0.01), but decreased in uninephrectomized rats treated with glucagon (p < 0.05). Absolute kidney weight gain and rates of renal DNA synthesis were also significantly blunted by glucagon infusion in uninephrectomized rats. These data suggest that ‘physiologic’ and ‘compensatory’ renal growth are governed by separate processes. Furthermore, the observation that glucagon promotes renal growth in intact nondiabetic animals supports its possible role as a growth factor in the early stages of diabetes.

show abstract

Insulin as a Growth‐Promoting Hormone

Messina

1999

Comprehensive Physiology

View full text Add to dashboard Cite

The sections in this article are: Insulin Actions and Signaling Growth‐Promoting Effects of Insulin on Cultured Cells Synergistic Actions of Insulin and Other Growth Factors in the Promotion of Cell Proliferation Insulin as A Growth‐Promoting Hormone in vivo Insulin as an Embryonic Growth Factor The Role of Insulin as an Embryonic Growth Factor in Rodents The Role of Insulin as an Embryonic Growth Factor in Chickens Leprechaunism and Rabson‐Mendenhall Syndrome Insulin and Liver Regeneration Knockout Mouse Models of Insulin Resistance How Insulin Induces Growth Regulation of Gene Expression by Insulin Insulin and Apoptosis Summary

show abstract

Acceleration of DNA synthesis in post-hepatectomized regenerating liver of normal rat by insulin and glucagon

Cited by 25 publications

References 8 publications

Liver regeneration following partial hepatectomy: genes and metabolism

Liver regeneration following partial hepatectomy: genes and metabolism

Effects of Glucagon on Physiologic and Compensatory Renal Growth in the Rat

Insulin as a Growth‐Promoting Hormone

Contact Info

Product

Resources

About