No abstract

We report a case of leiomyosarcoma in the bladder which occurred in an 18-year-old boy who had been treated with cyclophosphamide over a period of 6 years for retinoblastoma diagnosed 50 days postpartum. Total cystectomy and formation of an ileal conduit were performed. Three years after the operation, he was tumor-free.

Serum ECP may be a useful marker for monitoring and predicting the clinical course in asthma.

Summary:Case reportA 4-year-old boy was first noted to have severe anemia at A 4-year-old boy with Diamond-Blackfan anemia and a history of multiple transfusions underwent umbilical 1 month of age. An evaluation showed hemoglobin 50 g/l, white blood cell count 5.5 × 10 9 /l with normal distribution, cord blood transplantation from his HLA-identical female sibling born by vaginal delivery at 38 weeks. The platelet count 385 × 10 9 /l, and 0% reticulocyte. The bone marrow showed marked erythroid hypoplasia with no patient was prepared with busulfan, cyclophosphamide and antilymphocyte globulin. Methotrexate and cycloabnormal cells and a diagnosis of Diamond-Blackfan anemia was confirmed. He was 2680 g at birth, the product sporin A were given for the prophylaxis of GVHD. Regimen-related toxicity was not observed and successful of a full-term, uncomplicated gestation. The parents were healthy and there was no consanguinity or family history engraftment occurred, including the erythroid series. No evidence of acute or chronic GVHD has been of hematological disorders. Several therapeutic approaches including intravenous high-dose methylprednisolone and observed for 14 months after transplantation. This is the first case of successful umbilical cord blood transoral corticosteroids had been tried. However, they had only a transient effect on the progressive anemia, and the patient plantation to a patient with Diamond-Blackfan anemia. Keywords: cord blood transplantation; Diamondbecame steroid-resistant and transfusion-dependent. He received 60 units of filtered and irradiated packed red cells Blackfan anemia; childhood; hemosiderosis before transplantation without any iron-chelating therapy. His HLA-type was A24, 31; B51, 52; DR15(2), 4; DQ1, 4, and not identical to the parents and a sibling (father: Diamond-Blackfan anemia is a disorder of childhood A31, 33; B44, 52; DR15(2), 8; DQ1, mother: A24, 33; B44, characterized by normochromic-macrocytic anemia, reti-51; DR4, 13; DQ1, 4, brother: A31, 33; B44, 52). culocytopenia and a normocellular marrow with a selective At 3 years of age, he displayed signs of iron overload deficiency of erythroid progenitors. Most patients respond including elevations of serum transaminase, iron and ferrito corticosteroids initially. However, about 60% require tin. CT scan showed a marked increase in the density of chronic red cell transfusion and die in the second and third the liver parenchyma, which was consistent with liver decade of life as a result of hemosiderosis. 1 Allogeneic hemosiderosis. Echocardiography revealed mild left ven-BMT is already accepted as effective therapy for steroidtricular dilatation and grade II mitral regurgitation with norresistant, transfusion-dependent patients with Diamondmal wall mobility. His mother became pregnant and a girl Blackfan anemia. 2-5 However, the limited availability of was delivered vaginally at 38 weeks without any complisuitable donors remains a problem. Recently, unbilical cord cations. At the time of delivery, 70 ml of cord blood was b...

Summary:suppressive than CY alone. Prompted by this success, Storb et al 7 have used CY/ATG to condition patients with aplastic anemia for first transplant, resulting in 92% 3-year actuarial Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia survival. Based on favorable experience in Seattle, Horstmann et al, 8 Okamoto et al 9 and Bunin et al 10 reported (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical sibsimilar results, using a different source, dose, and time schedule of ATG. Here, we report our results of CY/ATG lings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg ) for 4 successive conditioning in 10 children with SAA; a durable engraftment rate of 100% in a median follow-up of 25 days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered months. Furthermore, in an effort to better understand the post-transplant experience of these patients, we compared as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of current results with published reports. 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results Patients and methods with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in From